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dc.contributor.authorZhou, Yi
dc.contributor.authorAlexandrov, Sergey
dc.contributor.authorNolan, Andrew
dc.contributor.authorDas, Nandan
dc.contributor.authorDey, Rajib
dc.contributor.authorLeahy, Martin
dc.date.accessioned2021-09-09T13:32:03Z
dc.date.available2021-09-09T13:32:03Z
dc.date.issued2020-02-17
dc.identifier.citationZhou, Yi, Alexandrov, Sergey, Nolan, Andrew, Das, Nandan, Dey, Rajib, & Leahy, Martin. (2020). Noninvasive detection of nanoscale structural changes in cornea associated with cross-linking treatment. Journal of Biophotonics, 13(6), e201960234. doi: https://doi.org/10.1002/jbio.201960234en_IE
dc.identifier.issn1864-063X
dc.identifier.urihttp://hdl.handle.net/10379/16932
dc.description.abstractCorneal cross-linking (CXL) using ultraviolet-A (UVA) irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as keratoconus. To characterize the corneal structural changes, existing methods such as X-ray microscopy, transmission electron microscopy, histology and optical coherence tomography (OCT) have been used. However, these methods have various drawbacks such as invasive detection, the impossibility for in vivo measurement, or limited resolution and sensitivity to structural alterations. Here, we report the application of oversampling nanosensitive OCT for probing the corneal structural alterations. The results indicate that the spatial period increases slightly after 30 minutes riboflavin instillation but decreases significantly after 30 minutes UVA irradiation following the Dresden protocol. The proposed noninvasive method can be implemented using existing OCT systems, without any additional components, for detecting nanoscale changes with the potential to assist diagnostic assessment during CXL treatment, and possibly to be a real-time monitoring tool in clinics.en_IE
dc.description.sponsorshipSTARSTEM, IMCUSTOMEYE, Grant/Award Numbers: 761214, 779960; Irish Research Council, Grant/Award Number: GOIPD/2017/837en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherWileyen_IE
dc.relation.ispartofJournal of biophotonicsen
dc.rightsCC BY-NC-ND 3.0 IE
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectOPTICAL COHERENCE TOMOGRAPHYen_IE
dc.subjectBIOMECHANICAL PROPERTIESen_IE
dc.subjectRABBIT CORNEAen_IE
dc.subjectKERATOCONUSen_IE
dc.subjectULTRAVIOLETen_IE
dc.subjectRIBOFLAVINen_IE
dc.subjectOCTen_IE
dc.titleNoninvasive detection of nanoscale structural changes in cornea associated with cross-linking treatmenten_IE
dc.typeArticleen_IE
dc.date.updated2021-09-01T09:56:27Z
dc.identifier.doi10.1002/jbio.201960234
dc.local.publishedsourcehttps://doi.org/10.1002/jbio.201960234en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderHorizon 2020en_IE
dc.contributor.funderIrish Research Councilen_IE
dc.internal.rssid20207362
dc.local.contactSergey Alexandrov, School Of Physics, Nui Galway. - Email: sergey.alexandrov@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionPUBLISHED
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/761214/EU/NanoSTARS imaging for STEM cell therapy for arthritic joints/STARSTEMen_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/779960/EU/IMaging-based CUSTOMised EYE diagnostics/IMCUSTOMEYEen_IE
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CC BY-NC-ND 3.0 IE
Except where otherwise noted, this item's license is described as CC BY-NC-ND 3.0 IE