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dc.contributor.authorDas, Nandan
dc.contributor.authorSergey, Alexandrov
dc.contributor.authorZhou, Yi
dc.contributor.authorGilligan, Katie E.
dc.contributor.authorDwyer, Róisín M.
dc.contributor.authorLeahy, Martin
dc.identifier.citationDas, Nandan, Sergey, Alexandrov, Zhou, Yi, Gilligan, Katie E., Dwyer, Róisín M., & Leahy, Martin. (2020). Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography. Nanoscale Advances, 2(7), 2853-2858. doi: 10.1039/D0NA00371Aen_IE
dc.description.abstractApproximately 90% of cancers originate in epithelial tissues leading to epithelial thickening, but the ultrastructural changes and underlying architecture are less well known. Depth resolved label free visualization of nanoscale tissue morphology is required to reveal the extent and distribution of ultrastructural changes in underlying tissue, but is difficult to achieve with existing imaging modalities. We developed a nanosensitive optical coherence tomography (nsOCT) approach to provide such imaging based on dominant axial structure with a few nanometre detection accuracy. nsOCT maps the distribution of axial structural sizes an order of magnitude smaller than the axial resolution of the system. We validated nsOCT methodology by detecting synthetic axial structure via numerical simulations. Subsequently, we validated the nsOCT technique experimentally by detecting known structures from a commercially fabricated sample. nsOCT reveals scaling with different depth of dominant submicron structural changes associated with carcinoma which may inform the origins of the disease, its progression and improve diagnosis.en_IE
dc.description.sponsorshipThis project received funding from Irish Research Council (IRC), under Government of Ireland postdoctoral fellowship with project ID: GOIPD/2017/837. Nandan Das acknowledge National University of Ireland Galway (NUIG) for research facilities. Also, this project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreements no. 761214 and no. 779960. The materials presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out. This work was supported by NUI Galway, Galway University Foundation, the University of Limerick Foundation, the National Biophotonics Imaging Platform (NBIP) Ireland funded under the Higher Education Authority PRTLI Cycle 4 and co-funded by the Irish Government and the European Union.en_IE
dc.publisherRoyal Society of Chemistryen_IE
dc.relation.ispartofNanoscale Advancesen
dc.rightsCC BY-NC-ND 3.0 IE
dc.subjectNanoscale structure detectionen_IE
dc.subjecttumour growthen_IE
dc.subjectoptical coherence tomographyen_IE
dc.titleNanoscale structure detection and monitoring of tumour growth with optical coherence tomographyen_IE
dc.contributor.funderIrish Research Councilen_IE
dc.contributor.funderHorizon 2020en_IE
dc.local.contactSergey Alexandrov, School Of Physics, Nui Galway. - Email:
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/761214/EU/NanoSTARS imaging for STEM cell therapy for arthritic joints/STARSTEMen_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/779960/EU/IMaging-based CUSTOMised EYE diagnostics/IMCUSTOMEYEen_IE

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