dc.contributor.author | Cormican, Sarah | |
dc.contributor.author | Griffin, Matthew D. | |
dc.date.accessioned | 2021-08-11T07:53:53Z | |
dc.date.available | 2021-08-11T07:53:53Z | |
dc.date.issued | 2020-06-04 | |
dc.identifier.citation | Cormican, Sarah, & Griffin, Matthew D. (2020). Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis. Frontiers in Immunology, 11(1070). doi:10.3389/fimmu.2020.01070 | en_IE |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | http://hdl.handle.net/10379/16895 | |
dc.description.abstract | Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing three monocyte subsets in humans. These phenotypic subsets, termed classical, intermediate and nonclassical, have also been demonstrated to differ in regard to their functional properties and disease associations when studiedin vitroandin vivo. Nonetheless, for the intermediate monocyte subset in particular, functional experiments have yielded conflicting results and some studies point to further levels of heterogeneity. Developments in genetic sequencing technology have provided opportunities to more comprehensively explore the phenotypic and functional differences among conventionally-recognized immune cell subtypes as well as the potential to identify novel subpopulations. In this review, we summarize the transcriptomic evidence in support of the existence of three separate monocyte subsets. We also critically evaluate the insights into subset functional distinctions that have been garnered from monocyte gene expression analysis and the potential utility of such studies to unravel subset-specific functional changes which arise in disease states. | en_IE |
dc.description.sponsorship | SC was supported by the Irish Clinical Academic Training (ICAT) Programme, supported by the Wellcome Trust and the Health Research Board (Grant Number 203930/B/16/Z), the Health Service Executive National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland. MG was supported by grants from the European Commission [Horizon 2020 Collaborative Health Project NEPHSTROM (grant number 634086) and FP7 Collaborative Health Project VISICORT (grant number 602470)] and from Science Foundation Ireland [CÚRAM Research Centre (grant number 13/RC/2073)] and by the European Regional Development Fund. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Frontiers Media | en_IE |
dc.relation.ispartof | Frontiers In Immunology | en |
dc.rights | Attribution 4.0 International (CC BY 4.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | BLOOD MONOCYTES | en_IE |
dc.subject | DENDRITIC CELLS | en_IE |
dc.subject | IDENTIFICATION | en_IE |
dc.subject | MACROPHAGES | en_IE |
dc.subject | ATHEROSCLEROSIS | en_IE |
dc.subject | HETEROGENEITY | en_IE |
dc.subject | TRANSCRIPTOME | en_IE |
dc.subject | SUBPOPULATION | en_IE |
dc.subject | INTERFERON | en_IE |
dc.subject | MICRORNAS | en_IE |
dc.title | Human monocyte subset distinctions and function: Insights from gene expression analysis | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2021-08-07T11:23:40Z | |
dc.identifier.doi | 10.3389/fimmu.2020.01070 | |
dc.local.publishedsource | https://doi.org/10.3389/fimmu.2020.01070 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | Wellcome Trust | en_IE |
dc.contributor.funder | Health Research Board | en_IE |
dc.contributor.funder | Health Service Executive National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland | en_IE |
dc.contributor.funder | Horizon 2020 | en_IE |
dc.contributor.funder | Seventh Framework Programme | en_IE |
dc.contributor.funder | Science Foundation Ireland | en_IE |
dc.contributor.funder | European Regional Development Fund | en_IE |
dc.internal.rssid | 21763539 | |
dc.local.contact | Matthew Dallas Griffin, Remedi, Biomedical Sciences Buil, Corrib Village, Dangan, Nui Galway. 5436 Email: matthew.griffin@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | PUBLISHED | |
dcterms.project | info:eu-repo/grantAgreement/EC/H2020::RIA/634086/EU/Novel Stromal Cell Therapy for Diabetic Kidney Disease/NEPHSTROM | en_IE |
dcterms.project | info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/602470/EU/Adverse Immune Signatures and their Prevention in Corneal Transplantation/VISICORT | en_IE |
dcterms.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/ | en_IE |
nui.item.downloads | 68 | |