dc.contributor.author | Sanz-Nogués, Clara | |
dc.contributor.author | O'Brien, Timothy | |
dc.date.accessioned | 2021-05-24T10:17:00Z | |
dc.date.available | 2021-05-24T10:17:00Z | |
dc.date.issued | 2016-06-01 | |
dc.identifier.citation | Sanz-Nogués, Clara, & O’Brien, Timothy. (2016). In vitro models for assessing therapeutic angiogenesis. Drug Discovery Today, 21(9), 1495-1503. doi:https://doi.org/10.1016/j.drudis.2016.05.016 | en_IE |
dc.identifier.issn | 1878-5832 | |
dc.identifier.uri | http://hdl.handle.net/10379/16780 | |
dc.description.abstract | Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of accessory vasculature to increase local tissue perfusion and to salvage tissue. However, this adaptive mechanism of repair is suboptimal in some patients. Therapeutic angiogenesis aims to stimulate new blood vessel formation via the local administration of proangiogenic agents or cell therapy products (CTPs). In this review, we provide a summary of the current understanding of in vitro models for assessing the angiogenic potential of a product. | en_IE |
dc.description.sponsorship | This work was funded by CÚRAM-Science Foundation of Ireland (SFI) Centre for Research in Medical
Devices (13/RC/2073). | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Elsevier | en_IE |
dc.relation.ispartof | Drug Discovery Today | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | neovascularization | en_IE |
dc.subject | therapeutic angiogenesis | en_IE |
dc.subject | arteriogenesis | en_IE |
dc.subject | cell therapy product | en_IE |
dc.subject | in vitro models | en_IE |
dc.subject | in vitro microvessels | en_IE |
dc.subject | mesenchymal stem/stromal cells | en_IE |
dc.subject | endothelial cells | en_IE |
dc.subject | capillary-like structures | en_IE |
dc.title | In vitro models for assessing therapeutic angiogenesis | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2021-05-24T09:51:04Z | |
dc.identifier.doi | 10.1016/j.drudis.2016.05.016 | |
dc.local.publishedsource | https://doi.org/10.1016/j.drudis.2016.05.016 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | Science Foundation Ireland | en_IE |
dc.internal.rssid | 26017790 | |
dc.local.contact | Clara Sanz Nogues, Remedi, Bioscience Building, Nui Galway. Email: clara.sanznogues@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
dcterms.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/ | en_IE |
nui.item.downloads | 91 | |