dc.contributor.author | La Gioia, Alessandra | |
dc.contributor.author | O'Halloran, Martin | |
dc.contributor.author | Porter, Emily | |
dc.date.accessioned | 2021-03-25T13:52:41Z | |
dc.date.available | 2021-03-25T13:52:41Z | |
dc.date.issued | 2020-06-09 | |
dc.identifier.citation | La Gioia, Alessandra, O’Halloran, Martin, & Porter, Emily. (2020). Challenges of Post-measurement Histology for the Dielectric Characterisation of Heterogeneous Biological Tissues. Sensors, 20(11), 3290. doi:10.3390/s20113290 | en_IE |
dc.identifier.issn | 1424-8220 | |
dc.identifier.uri | http://hdl.handle.net/10379/16640 | |
dc.description.abstract | The dielectric properties of biological tissues are typically measured using the open-ended coaxial probe technique, which is based on the assumption that the tissue sample is homogeneous. Therefore, for heterogeneous tissue samples, additional post-measurement sample processing is conducted. Specifically, post-measurement histological analysis may be performed in order to associate the measured dielectric properties with the tissue types present in a heterogeneous sample. Accurate post-measurement histological analysis enables identification of the constituent tissue types that contributed to the measured dielectric properties, and their relative distributions. There is no standard protocol for conducting post-measurement histological analysis, which leads to high numbers of excluded tissue samples and inconsistencies in the resulting reported data for heterogeneous tissues. To this extent, this study examines the post-measurement histological process and the challenges in associating the acquired dielectric properties with the different tissue types present in heterogeneous samples. The results demonstrate that the histological process inevitably alters the morphology of samples, thus introducing errors in the interpretation of the dielectric properties acquired from heterogeneous biological samples. Notably, sample size was seen to shrink by up to 90% through the histological process, meaning that sensing volume determined from fresh tissues is not directly applicable to histology images. | en_IE |
dc.description.sponsorship | The research leading to these results has received funding from the European Research Council under the European Union’s Horizon 2020 Programme/ERC Grant Agreement BioElecPro n. 637780. This work was also supported by Science Foundation Ireland (SFI) (grant number 15/ERCS/3276), and the Hardiman Research Scholarship from the National University of Ireland Galway. This work has been developed in the framework of COST Action MyWAVE (CA17115). | |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | MDPI | en_IE |
dc.relation.ispartof | Sensors | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | dielectric measurements | en_IE |
dc.subject | biological tissues | en_IE |
dc.subject | open-ended coaxial probe technique | en_IE |
dc.subject | histology | en_IE |
dc.title | Challenges of post-measurement histology for the dielectric characterisation of heterogeneous biological tissues | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2021-03-19T15:29:58Z | |
dc.identifier.doi | 10.3390/s20113290 | |
dc.local.publishedsource | https://doi.org/10.3390/s20113290 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | European Research Council | |
dc.contributor.funder | Science Foundation Ireland | |
dc.contributor.funder | Hardiman Research Scholarship, National University of Ireland Galway | |
dc.internal.rssid | 25272247 | |
dc.local.contact | Martin O'Halloran, School Of E&I/School Of Medicine, Nui Galway. 5072 Email: martin.ohalloran@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dcterms.project | info:eu-repo/grantAgreement/EC/H2020::ERC::ERC-STG/637780/EU/Frontier Research on the Dielectric Properties of Biological Tissue/BIOELECPRO | |
dcterms.project | 15/ERCS/3276 | |
nui.item.downloads | 61 | |