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dc.contributor.authorMente, Andrew
dc.contributor.authorO'Donnell, Martin
dc.contributor.authorSumathy Rangarajan, Sumathy
dc.contributor.authorDagenais, Gilles
dc.contributor.authorLear, Scott
dc.contributor.authorMcQueen, Matthew
dc.contributor.authorDiaz, Rafael
dc.contributor.authorAvezum, Alvaro
dc.contributor.authorLopez-Jaramillo, Patricio
dc.contributor.authorLanas, Fernando
dc.contributor.authorLi, Wei
dc.contributor.authorLu, Yin
dc.contributor.authorYi, Sun
dc.contributor.authorRensheng, Lei
dc.contributor.authorIqbal, Romaina
dc.contributor.authorMony, Prem
dc.contributor.authorYusuf, Rita
dc.contributor.authorYusoff, Khalid
dc.contributor.authorSzuba, Andrzej
dc.contributor.authorOguz, Aytekin
dc.contributor.authorRosengren, Annika
dc.contributor.authorBahonar, Ahmad
dc.contributor.authorYusufali, Afzalhussein
dc.contributor.authorSchutte, Aletta Elisabeth
dc.contributor.authorChifamba, Jephat
dc.contributor.authorMann, Johannes F. E.
dc.contributor.authorAnand, Sonia S.
dc.contributor.authorTeo, Koon
dc.contributor.authorYusuf, S.
dc.date.accessioned2021-03-24T09:49:23Z
dc.date.available2021-03-24T09:49:23Z
dc.date.issued2016-05-20
dc.identifier.citationMente, A,O'Donnell, M,Rangarajan, S,Dagenais, G,Lear, S,McQueen, M,Diaz, R,Avezum, A,Lopez-Jaramillo, P,Lanas, F,Wei, L,Yin, L,Sun, Y,Lei, R,Iqbal, RS,Mony, P,Yusuf, R,Yusoff, K,Szuba, A,Oguz, A,Rosengren, A,Bahonar, A,Yusufali, A,Schutte, AE,Chifamba, J,Mann, JFE,Anand, SS,Teo, K,Yusuf, S,PURE Investigator,EPIDREAM Investigator,TARGET TRANSCEND Investigator (2016) 'Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies'. Lancet, 388 :465-475. doi:10.1016/S0140-6736(16)30467-6en_IE
dc.identifier.issn1474-547X
dc.identifier.urihttp://hdl.handle.net/10379/16625
dc.description.abstractBackground Several studies reported a U-shaped association between urinary sodium excretion and cardiovascular disease events and mortality. Whether these associations vary between those individuals with and without hypertension is uncertain. We aimed to explore whether the association between sodium intake and cardiovascular disease events and all-cause mortality is modified by hypertension status.Methods In this pooled analysis, we studied 133 118 individuals (63 559 with hypertension and 69 559 without hypertension), median age of 55 years (IQR 45-63), from 49 countries in four large prospective studies and estimated 24-h urinary sodium excretion (as group-level measure of intake). We related this to the composite outcome of death and major cardiovascular disease events over a median of 4.2 years (IQR 3.0-5.0) and blood pressure.Findings Increased sodium intake was associated with greater increases in systolic blood pressure in individuals with hypertension (2.08 mm Hg change per g sodium increase) compared with individuals without hypertension (1.22 mm Hg change per g; p(interaction) = 7 g/day in 6271 [9%] of the population without hypertension; HR 0.90 [95% CI 0.76-1.08]; p = 0.2547), whereas an excretion of less than 3 g/day was associated with a significantly increased risk (7547 [11%] of the population without hypertension; HR 1.26 [95% CI 1.10-1.45]; p = 0.0009).Interpretation Compared with moderate sodium intake, high sodium intake is associated with an increased risk of cardiovascular events and death in hypertensive populations (no association in normotensive population), while the association of low sodium intake with increased risk of cardiovascular events and death is observed in those with or without hypertension. These data suggest that lowering sodium intake is best targeted at populations with hypertension who consume high sodium diets.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofLanceten
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectLOW-INCOME COUNTRIESen_IE
dc.subjectHIGH-RISK PATIENTSen_IE
dc.subjectRANDOMIZED CONTROLLED-TRIALen_IE
dc.subjectCONGESTIVE-HEART-FAILUREen_IE
dc.subjectBLOOD-PRESSURE CONTROLen_IE
dc.subjectPLASMA-RENIN ACTIVITYen_IE
dc.subjectPOTASSIUM EXCRETIONen_IE
dc.subjectLOWERING TREATMENTen_IE
dc.subjectSALT INTAKEen_IE
dc.subjectSPOT URINEen_IE
dc.titleAssociations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studiesen_IE
dc.typeArticleen_IE
dc.date.updated2021-03-23T09:02:16Z
dc.identifier.doi10.1016/S0140-6736(16)30467-6
dc.local.publishedsourcehttps://doi.org/10.1016/S0140-6736(16)30467-6en_IE
dc.description.peer-reviewedpeer-reviewed
dc.internal.rssid11519717
dc.local.contactMartin James O'Donnell, Medicine, Nui Galway. Email: martin.odonnell@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
nui.item.downloads249


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