dc.contributor.author | Ejiugwo, Mirella | |
dc.contributor.author | Shaw, Georgina | |
dc.contributor.author | Barry, Frank | |
dc.contributor.author | Krawczyk, Janusz | |
dc.contributor.author | McInerney, Veronica | |
dc.date.accessioned | 2021-01-19T11:27:15Z | |
dc.date.available | 2021-01-19T11:27:15Z | |
dc.date.issued | 2019-12-05 | |
dc.identifier.citation | Ejiugwo, Mirella, Shaw, Georgina, Barry, Frank, Krawczyk, Janusz, & McInerney, Veronica. (2019). The motivational factors and adverse events experienced by healthy volunteers donating bone marrow for research. International Journal of Bone Marrow Research, 2, 089-096. doi:10.29328/journal.ijbmr.1001010 | en_IE |
dc.identifier.uri | http://hdl.handle.net/10379/16474 | |
dc.description.abstract | Background: With the advancement of cell therapy research, there is an increasing need for
healthy volunteers (HV) to donate small volumes (30 ml) of human bone marrow (BM). The BM procedure required to procure small volumes is invasive, although short-lived (25 seconds), is
not without risk. To ensure a sustainable supply of BM for research and cell therapy, greater information of the risks and factors that motivate HV to donate small volumes of BM will help
optimize the procedure and HV enrolment, ensuring donors are fully informed of the potential risks.
Objective: To identify the adverse events (AE) experienced by HV during and after small volume BM procedure and understand the motivating factors that infl uence HV to donate BM
for research.
Method: HV (n = 55) who donated BM (30 ml) for scientifi c research and provided informed consent were administered a questionnaire to identify the type, duration and severity of AE
experienced during and post-BM aspiration; and to determine the motivating factors that influenced their willingness to donate BM.
Results: Pain was experienced by 89% of participants during the BM procedure with moderate grade reported by 40%. One/more of the following AE were experienced by 73% of the volunteers
post-BM procedure: pain, fatigue, site reaction, nausea and transient hypotension. AE resolved within an average of three days. The reported motivational factors ranked in the following order:first, to advance research for the benefit of future patients; compensation for participation; free medical check-up; lastly, the research question was interesting.
Conclusion: Young HV, motivated primarily by altruism and financial compensation, risk the
occurrence of transient AE following donation of small-volume BM for research. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Heighten Science Publications Corporation (HSPC) | en_IE |
dc.relation.ispartof | Int J Bone Marrow Res | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Bone marrow donation; Mesenchymal | en_IE |
dc.subject | Bone marrow donation | en_IE |
dc.subject | Mesenchymal | en_IE |
dc.subject | Motivational factors for bone marrow donation | en_IE |
dc.subject | Healthy volunteers | en_IE |
dc.subject | Adverse events | en_IE |
dc.subject | Stromal cell research | en_IE |
dc.title | The motivational factors and adverse events experienced by healthy volunteers donating bone marrow for research | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2021-01-18T14:53:01Z | |
dc.identifier.doi | 10.29328/journal.ijbmr.1001010 | |
dc.local.publishedsource | https://dx.doi.org/10.29328/journal.ijbmr.1001010 | en_IE |
dc.description.peer-reviewed | Not peer reviewed | |
dc.internal.rssid | 24422536 | |
dc.local.contact | Veronica Mcinerney, Hrb Clinical Research Facilty, University Road, Nui Galway. Email: veronica.mcinerney@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 138 | |