Microcavity array supported lipid bilayer models of ganglioside – influenza hemagglutinin1 binding
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Date
2020-08-07Author
Berselli, Guilherme B.
Sarangi, Nirod Kumar
Gimenez, Aurélien V.
Murphy, Paul V.
Keyes, Tia E.
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Berselli, Guilherme B., Sarangi, Nirod Kumar, Gimenez, Aurélien V., Murphy, Paul V., & Keyes, Tia E. (2020). Microcavity array supported lipid bilayer models of ganglioside – influenza hemagglutinin1 binding. Chemical Communications, 56(76), 11251-11254. doi:10.1039/D0CC04276E
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Abstract
The binding of influenza receptor (HA(1)) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA(1)preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA(1)GM1 or GM3.