Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential
Date
2019-12-05Author
Griffin, Tomás Patrick
Islam, Md Nahidul
Wall, Deirdre
Ferguson, John
Griffin, Damian Gerard
Griffin, Matthew D.
O’Shea, Paula M.
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Recommended Citation
Griffin, Tomás Patrick, Islam, Md Nahidul, Wall, Deirdre, Ferguson, John, Griffin, Damian Gerard, Griffin, Matthew Dallas, & O’Shea, Paula M. (2019). Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential. Scientific Reports, 9(1), 18452. doi:10.1038/s41598-019-54762-2
Published Version
Abstract
Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and to explore the potential utility of dp-ucMGP in patients with diabetes mellitus (DM) with and without diabetic kidney disease (DKD). Healthy volunteers (HVs) (cross-sectional study) and participants with DM (prospective cohort study) were recruited. Plasma dp-ucMGP was measured using the IDS®-iSYS Ina Ktif (dp-ucMGP) assay. Of the HVs recruited (n = 208), 67(32.2%) were excluded leaving a reference population of 141(67.8%) metabolically healthy participants with normal kidney function. Plasma dp-ucMGP RIs were