Show simple item record

dc.contributor.advisorQuinlan, Nathan
dc.contributor.authorHassanzadeh Moghimi, Mohsen
dc.description.abstractIn Aerogen aerosol drug delivery technology, an aperture plate vibrates at high frequency under a piezoelectric drive. Liquid drug stored on one side of the plate passes through the apertures to form an aerosol of microscopic droplets, which can be inhaled. A computational fluid dynamics (CFD) technique based on the finite volume particle method (FVPM) was developed to capture the physics of droplet formation in a single aperture. Two novel extensions to the modelling capability of FVPM are presented in this thesis. Firstly, a kinematic criterion for free surface extension (KCFSE) was developed to differentiate physical free surfaces from spurious numerical voids. The novel method enables background pressure to be applied at physical free surfaces and throughout the fluid, but not in non-physical voids, facilitating the suppression of spurious voids. The results obtained are in good agreement with benchmark data. Secondly, a surface tension model was developed in the FVPM. We present a model in which the direction of the pairwise surface tension force is approximated by the common tangent of free-surface particle supports. The results are in good agreement with theoretical and experimental data. Since each aperture in Aerogen's nebulizer is approximately axially symmetric, axisymmetric simulations of the flow field were performed for surface-tension-dominated flows. The results demonstrate the accuracy of the surface tension model in axisymmetric FVPM. Finally, FVPM simulations were performed for an oscillating single aperture in microscale and millimetre-scale to investigate the fluid dynamics of droplet formation. The simulations show good agreement with the observations from an experiment on a millimetre-scale single aperture. In the simulation of a microscale single aperture, the effects of the liquid properties and aperture plate operating conditions on liquid column breakup and drop formation were studied. The simulations show that breakup of liquid columns is associated with Rayleigh theory of instability.en_IE
dc.publisherNUI Galway
dc.subjectFinite volume particle methoden_IE
dc.subjectSurface tensionen_IE
dc.subjectCylinder impact on liquiden_IE
dc.subjectFree surfaceen_IE
dc.subjectcapillary instabilityen_IE
dc.subjectjet breakupen_IE
dc.subjectVibrating Mesh Nebulizeren_IE
dc.subjectScience and Engineeringen_IE
dc.subjectMechanical Engineeringen_IE
dc.titleInvestigation of fluid dynamics in a vibrating mesh nebulizer using the finite volume particle methoden_IE
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.local.noteMicrouidic droplet generation has an important role in industrial applications such as Aerogen's nebulizer. So, prediction of the behaviour of this type of flow field has high significance. Our research shows the application of meshless method in the simulation of liquid ejection and drop formation in the drug delivery technology.en_IE
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/en_IE

Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:


This item appears in the following Collection(s)

Show simple item record