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dc.contributor.authorCinelli, Ilaria
dc.contributor.authorDestrade, Michel
dc.contributor.authorMcHugh, Peter
dc.contributor.authorTrotta, Antonia
dc.contributor.authorGilchrist, Michael
dc.contributor.authorDuffy, Maeve
dc.identifier.citationCinelli, Ilaria, Destrade, Michel, McHugh, Peter, Trotta, Antonia, Gilchrist, Michael, & Duffy, Maeve. (2019). Head-to-nerve analysis of electromechanical impairments of diffuse axonal injury. Biomechanics and Modeling in Mechanobiology, 18(2), 361-374. doi:10.1007/s10237-018-1086-8en_IE
dc.description.abstractThe aim was to investigate mechanical and functional failure of diffuse axonal injury (DAI) in nerve bundles following frontal head impacts, by finite element simulations. Anatomical changes following traumatic brain injury are simulated at the macroscale by using a 3D head model. Frontal head impacts at speeds of 2.5-7.5 m/s induce mild-to-moderate DAI in the white matter of the brain. Investigation of the changes in induced electromechanical responses at the cellular level is carried out in two scaled nerve bundle models, one with myelinated nerve fibres, the other with unmyelinated nerve fibres. DAI occurrence is simulated by using a real-time fully coupled electromechanical framework, which combines a modulated threshold for spiking activation and independent alteration of the electrical properties for each three-layer fibre in the nerve bundle models. The magnitudes of simulated strains in the white matter of the brain model are used to determine the displacement boundary conditions in elongation simulations using the 3D nerve bundle models. At high impact speed, mechanical failure occurs at lower strain values in large unmyelinated bundles than in myelinated bundles or small unmyelinated bundles; signal propagation continues in large myelinated bundles during and after loading, although there is a large shift in baseline voltage during loading; a linear relationship is observed between the generated plastic strain in the nerve bundle models and the impact speed and nominal strains of the head model. The myelin layer protects the fibre from mechanical damage, preserving its functionalities.en_IE
dc.description.sponsorshipThe authors acknowledge funding from the Galway University Foundation, the Biomechanics Research Centre and the Power Electronics Research Centre, College of Engineering and Informatics, NUI Galway (Galway, Republic of Ireland).en_IE
dc.relation.ispartofBiomechanics And Modeling In Mechanobiologyen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectCoupled electromechanical modellingen_IE
dc.subjectFinite element modellingen_IE
dc.subjectDiffuse axonal injuryen_IE
dc.titleHead-to-nerve analysis of electromechanical impairments of diffuse axonal injuryen_IE
dc.contributor.funderGalway University Foundationen_IE
dc.contributor.funderCollege of Engineering and Informatics, National University of Ireland, Galwayen_IE
dc.local.contactMichel Destrade, Room Adb-1002, Áras De Brun, School Of Mathematics, Nui Galway. 2344 Email:

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