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dc.contributor.authorFinn, David P.
dc.contributor.authorJhaveri, M.D.
dc.contributor.authorJhaveri, Maulik D.
dc.contributor.authorBeckett, Simon Richard Graham
dc.contributor.authorRoe, Clare H.
dc.contributor.authorKendall, David A.
dc.contributor.authorMarsden, Charles Alexander
dc.contributor.authorChapman, Victoria
dc.date.accessioned2020-11-02T09:14:18Z
dc.date.available2020-11-02T09:14:18Z
dc.date.issued2003-07-31
dc.identifier.citationFinn, D. P., Jhaveri, M. D., Beckett, S. R. G., Roe, C. H., Kendall, D. A., Marsden, C. A., & Chapman, V. (2003). Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats. Neuropharmacology, 45(5), 594-604. doi:https://doi.org/10.1016/S0028-3908(03)00235-1en_IE
dc.identifier.issn0028-3908
dc.identifier.urihttp://hdl.handle.net/10379/16252
dc.description.abstractThe analgesic potential of cannabinoids may be hampered by their ability to produce aversive emotion when administered systemically. We investigated the hypothesis that the midbrain periaqueductal grey (PAG) is a common substrate mediating the anti-nociceptive and potential aversive effects of cannabinoids. The rat formalin test was used to model nociceptive behaviour. Intra-PAG microinjection of the excitatory amino acid d,l-homocysteic acid (DLH) was used to induce an aversive, panic-like reaction characteristic of the defensive “fight or flight” response. Administration of the cannabinoid receptor agonist HU210 (5 μg/rat) into the dorsal PAG significantly reduced the second phase of formalin-evoked nociceptive behaviour, an effect which was blocked by co-administration of the CB1 receptor antagonist SR141716A (50 μg/rat). This anti-nociceptive effect was accompanied by an HU210-induced attenuation of the formalin-evoked increase in Fos protein expression in the caudal lateral PAG. Intra-dorsal PAG administration of HU210 (0.1, 1 or 5 μg/rat) significantly reduced the aversive DLH-induced explosive locomotor response. The anti-nociceptive effect of HU210 is likely to result from activation of the descending inhibitory pain pathway. Mechanisms mediating the anti-aversive effects of cannabinoids in the PAG remain to be elucidated. These data implicate a role for the PAG in both cannabinoid-mediated anti-nociceptive and anti-aversive responses.en_IE
dc.description.sponsorshipThis work was supported by The Wellcome Trusten_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofNeuropharmacologyen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectCannabinoid receptoren_IE
dc.subjectPainen_IE
dc.subjectPeriaqueductal greyen_IE
dc.subjectAversionen_IE
dc.subjectFormalin testen_IE
dc.subjectPanicc-Fosen_IE
dc.titleEffects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in ratsen_IE
dc.typeArticleen_IE
dc.date.updated2020-10-30T01:59:34Z
dc.identifier.doi10.1016/S0028-3908(03)00235-1
dc.local.publishedsourcehttps://doi.org/10.1016/S0028-3908(03)00235-1en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderWellcome Trusten_IE
dc.internal.rssid1140961
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionPUBLISHED
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland