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dc.contributor.authorConnolly, Alison
dc.contributor.authorCoggins, Marie A.
dc.contributor.authorKoch, Holger M.
dc.date.accessioned2020-08-19T09:07:58Z
dc.date.available2020-08-19T09:07:58Z
dc.date.issued2020-08-18
dc.identifier.citationConnolly, Alison, Coggins, Marie A., & Koch, Holger M. (2020). Human biomonitoring of glyphosate exposures: State-of-the-art and future research challenges. Toxics, 8(3), 60. doi:10.3390/toxics8030060en_IE
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10379/16135
dc.description.abstractAbstract: Glyphosate continues to attract controversial debate following the International Agency for Research on Cancer carcinogenicity classification in 2015. Despite its ubiquitous presence in our environment, there remains a dearth of data on human exposure to both glyphosate and its main biodegradation product aminomethylphosphonic (AMPA). Herein, we reviewed and compared results from 21 studies that use human biomonitoring (HBM) to measure urinary glyphosate and AMPA. Elucidation of the level and range of exposure was complicated by differences in sampling strategy, analytical methods, and data presentation. Exposure data is required to enable a more robust regulatory risk assessment, and these studies included higher occupational exposures, environmental exposures, and vulnerable groups such as children. There was also considerable uncertainty regarding the absorption and excretion pattern of glyphosate and AMPA in humans. This information is required to back-calculate exposure doses from urinary levels and thus, compared with health-based guidance values. Back-calculations based on animal-derived excretion rates suggested that there were no health concerns in relation to glyphosate exposure (when compared with EFSA acceptable daily intake (ADI)). However, recent human metabolism data has reported as low as a 1% urinary excretion rate of glyphosate. Human exposures extrapolated from urinary glyphosate concentrations found that upper-bound levels may be much closer to the ADI than previously reported.en_IE
dc.description.sponsorshipThe lead author has received funding from the Irish Research Council and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 713279en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherMDPIen_IE
dc.relation.ispartofToxicsen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectGlyphosateen_IE
dc.subjectaminomethylphosphonic aciden_IE
dc.subjectAMPAen_IE
dc.subjecturineen_IE
dc.subjecthuman biomonitoringen_IE
dc.subjectenvironmental exposuresen_IE
dc.subjecttoxicokineticsen_IE
dc.subjectexposure assessmenten_IE
dc.subjectrisk assessmenten_IE
dc.titleHuman biomonitoring of glyphosate exposures: State-of-the-art and future research challengesen_IE
dc.typeArticleen_IE
dc.date.updated2020-08-18T13:49:35Z
dc.identifier.doi10.3390/toxics8030060
dc.local.publishedsourcehttps://doi.org/10.3390/toxics8030060en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderIrish Research Councilen_IE
dc.contributor.funderHorizon 2020en_IE
dc.internal.rssid22249126
dc.local.contactMarie Coggins, School Of Physics, Room 212, Arts/Science Building, Nui Galway. 5056 Email: marie.coggins@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionPUBLISHED
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713279/EU/Collaborative Research Fellowships for a Responsive and Innovative Europe/CAROLINEen_IE
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland