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Now showing items 21-29 of 29
Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
(2015-04)
Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial ...
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society Publishing, 2012-07-18)
The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ...
A thermodynamically motivated model for stress-fiber reorganization
(Springer Verlag, 2015-09-04)
We present a model for stress-fiber reorganization and the associated contractility that includes both the kinetics of stress-fiber formation and dissociation as well as the kinetics of stress-fiber remodeling. These ...
Anatomically and dielectrically realistic microwave head phantom with circulation and reconfigurable lesions
(The Electromagnetics Academy, 2017)
Phantoms provide valuable test platforms for developing medical devices. Solid materials in particular allow fabrication of stable and robust models. This paper presents a novel, anatomically realistic, multi-layered head ...
Evaluation of a multiscale modelling methodology to predict the mechanical properties of PCL/β-TCP sintered scaffold materials
(Springer Verlag, 2014-12-02)
A multiscale modelling methodology to predict the macroscale stiffness of selective laser sintered polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) materials is evaluated. The relationship between a micromechanics-evaluated ...
Design and manufacturing of customised maxillofacial prostheses.
(Elsevier, 2003-04-28)
Customised implants created by Computer-Assisted Surgery (CAS) techniques and used in
maxillofacial reconstruction indicate improved outcomes over conventional techniques.
‘‘Non-functional’’ multistaged procedures are ...
A unified viscoplastic model for high temperature low cycle fatigue of service-aged P91 steel
(American Society of Mechanical Engineers, 2014-01-07)
The finite element (FE) implementation of a hyperbolic sine unified cyclic viscoplasticity model is presented. The hyperbolic sine flow rule facilitates the identification of strain-rate independent material parameters for ...
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
(AO Research Institute Davos, 2016-05-26)
Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ...
Improving the finite element model accuracy of tissue engineered scaffolds produced by selective laser sintering
(Springer Verlag, 2015-01-13)
In bone tissue engineering, both geometrical and mechanical properties of a scaffold play a major part in the success of the treatment. The mechanical stresses and strains that act on cells on a scaffold in a physiological ...