Now showing items 1-4 of 4
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ...
Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo
Introduction: During endochondral ossification, both the production of a cartilage template and the subsequent vascularisation of that template are essential precursors to bone tissue formation. Recent studies have found ...
Thermally induced osteocyte damage initiates a remodelling signaling cascade
(Public Library of Science, 2015-03-18)
Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ...
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
(Biophysical Society, 2015-04-07)
Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ...