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Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis
(Biophysical Society, 2015-04-07)
Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical environment of bone cells and may thereby initiate a mechanobiological response. It has proved challenging to characterize the ...
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer, 2014-11-15)
Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ...
The role of integrin αVβ3 in osteocyte mechanotransduction
(Elsevier, 2014-11-10)
Recent in vivo studies have proposed that integrin alpha(v)beta(3) attachments between osteocyte cell processes and the extracellular matrix may facilitate mechanosensation in bone. However the role of these attachments ...
Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
(Elsevier, 2015-01-14)
Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the ...
An FPGA-based stereoscopic camera - electronic design tools and techniques
(IEEE, 2010-08-05)
Electronic design tools and techniques for the implementation of a stereoscopic camera based on an FPGA (Field Programmable Gate Array) are presented. The stages of an IPP (Image Processing Pipeline) are presented together ...
Polarity assessment of thermoresponsive poly(NIPAM-co-NtBA) copolymer films using fluorescence methods.
(Springer, 2010)
The in-situ, non-contact, and non-destructive measurement of the physicochemical properties such as the polarity of thin, hydrophilic polymer films is desirable in many areas of polymer science. Polarity is a complex factor ...
Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants
(Springer Verlag, 2014-10-04)
Abstract Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which ...
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
(Biophysical Society, 2015-04-07)
Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ...
Development of a global energy management system for the life sciences industry: an energy management maturity model implementation
(NUI Galway, 2015-11)
The Global Energy Management System (GEMS) research project proposes a novel methodology for assessing capital energy-efficiency projects at a global level. The paper scope covers the systematic development and implementation ...
Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
(Wiley, 2013-12-03)
Bone continuously adapts its internal structure to accommodate the
functional demands of its mechanical environment. This process is
orchestrated by a network of mechanosensitive osteocytes that respond to
external ...