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Project management for engineers
(National University of Ireland, Galway, 2016)
In recent years we have witnessed a rapid growth in the use of project management
methods and tools as a means by which organisations achieve their objectives. Projects
drive business in industries as diverse as ...
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
(Elsevier, 2014-02-11)
Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ...
Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered PCL/b-TCP materials
(Elsevier, 2015-06-06)
Orthopaedic scaffold materials were fabricated from polycaprolactone (PCL) and composite PCL β-tricalcium phosphate (PCL/β-TCP) powders using selective laser sintering (SLS). Incorporating β-TCP particles is ...
A thermodynamically motivated model for stress-fiber reorganization
(Springer Verlag, 2015-09-04)
We present a model for stress-fiber reorganization and the associated contractility that includes both the kinetics of stress-fiber formation and dissociation as well as the kinetics of stress-fiber remodeling. These ...
Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
(Springer Verlag, 2013-06-18)
Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ...
Statistical grain size effects in fretting crack initiation
(Elsevier, 2016-09-20)
A crystal plasticity computational framework is developed and validated to investigate the microstructure sensitivity of crack initiation in fretting. Randomly distributed microstructure geometries are incorporated into a ...
The tensile ductility of cellular solids: the role of imperfections
(Elsevier, 2016-10-11)
Metallic and polymeric foams typically possess a low tensile failure strain of a few percent despite the fact that the parent solid can have high ductility (10% or more). This is remarkable as foams are bending-dominated ...
Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions
(Elsevier, 2014-11-27)
We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces ...
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)
Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ...
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society Publishing, 2012-07-18)
The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ...