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Mechanisms of osteocyte stimulation in osteoporosis
(Elsevier, 2016-05-10)
Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ...
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
(Elsevier, 2013-07-18)
Osteocytes are terminally differentiated bone cells, derived from
osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding
density have been shown to regulate osteoblast ...
Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered PCL/b-TCP materials
(Elsevier, 2015-06-06)
Orthopaedic scaffold materials were fabricated from polycaprolactone (PCL) and composite PCL β-tricalcium phosphate (PCL/β-TCP) powders using selective laser sintering (SLS). Incorporating β-TCP particles is ...
A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone
(Elsevier, 2012-03-20)
Bone is an exceptional material that is lightweight for efficient movement but also exhibits excellent strength and stiffness imparted by a composite material of organic proteins and mineral crystals that are intricately ...
3D Printing of Microspheres for Tissue Engineering Scaffolds
(Mary Ann Liebert, 2015-09)
Microspheres have tremendous potential as a scaffold material for tissue engineering applications due to their capability of encapsulation and controlled release of factors that assist tissue regeneration in the desired ...
Experimental mechanical testing of Poly (l-Lactide) (PLLA) to facilitate pre-degradation characteristics for application in cardiovascular stenting
(Elsevier, 2016-07-19)
Next-generation stents made from Biodegradable Polymers (BPs) aim to address the long-term risks (i.e. late restenosis and in-stent thrombosis) associated with both Bare Metal Stents and Drug Eluting Stents, whilst aiming ...
Bridging the osteochondral gap in mandibular condyle reconstruction with multiphasic 3D printing
(Mary Ann Liebert, 2015-09)
Individuals afflicted with temporomandibular joint disorders experience a reduced ability to perform the most basic human functions such as chewing and talking. In advanced disease states, total joint replacement is often ...
Project management for engineers
(National University of Ireland, Galway, 2016)
In recent years we have witnessed a rapid growth in the use of project management
methods and tools as a means by which organisations achieve their objectives. Projects
drive business in industries as diverse as ...
Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach
(Springer Verlag, 2013-04-09)
Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ...
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
(The Royal Society Publishing, 2012-06-06)
The osteocyte is believed to act as the main sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on our bones throughout life. ...