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dc.contributor.authorMcPhilemy, Genevieve
dc.contributor.authorNabulsi, Leila
dc.contributor.authorKilmartin, Liam
dc.contributor.authorO’Hora, Denis
dc.contributor.authorO’Donoghue, Stefani
dc.contributor.authorTronchin, Giulia
dc.contributor.authorCostello, Laura
dc.contributor.authorNajt, Pablo
dc.contributor.authorAmbati, Srinath
dc.contributor.authorNeilsen, Gráinne
dc.contributor.authorCreighton, Sarah
dc.contributor.authorByrne, Fintan
dc.contributor.authorMcLoughlin, James
dc.contributor.authorMcDonald, Colm
dc.contributor.authorHallahan, Brian
dc.contributor.authorCannon, Dara M.
dc.date.accessioned2020-06-05T10:44:21Z
dc.date.issued2019-09-18
dc.identifier.citationMcPhilemy, Genevieve, Nabulsi, Leila, Kilmartin, Liam, O’Hora, Denis, O’Donoghue, Stefani, Tronchin, Giulia, Costello, Laura, Najt, Pablo, Ambati, Srinath, Neilsen, Gráinne, Creighton, Sarah, Byrne, Fintan, McLoughlin, James, McDonald, Colm Hallahan, Brian, Cannon, Dara M. (2020). Neuroanatomical Dysconnectivity Underlying Cognitive Deficits in Bipolar Disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(2), 152-162. doi: 10.1016/j.bpsc.2019.09.004en_IE
dc.identifier.issn2451-9022
dc.identifier.urihttp://hdl.handle.net/10379/16009
dc.description.abstractBACKGROUND: Graph theory applied to brain networks is an emerging approach to understanding the brain's topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder (BD) and recent reports of altered anatomical network organization, the association between connectivity and cognitive impairments in BD remains unclear.METHODS: We examined the role of anatomical network connectivity derived from Ti - and diffusion-weighted magnetic resonance imaging in impaired cognitive performance in individuals with BD (n = 32) compared with healthy control individuals (n = 38). Fractional anisotropy- and number of streamlines-weighted anatomical brain networks were generated by mapping constrained spherical deconvolution-reconstructed white matter among 86 cortical/subcortical bilateral brain regions delineated in the individual's own coordinate space. Intelligence and executive function were investigated as distributed functions using measures of global, rich-club, and interhemispheric connectivity, while memory and social cognition were examined in relation to subnetwork connectivity.RESULTS: Lower executive functioning related to higher global clustering coefficient in participants with BD, and lower IQ performance may present with a differential relationship between global and interhemispheric efficiency in individuals with BD relative to control individuals. Spatial recognition memory accuracy and response times were similar between diagnostic groups and associated with basal ganglia and thalamus interconnectivity and connectivity within extended anatomical subnetworks in all participants. No anatomical subnetworks related to episodic memory, short-term memory, or social cognition generally or differently in BD.CONCLUSIONS: Results demonstrate selective influence of subnetwork patterns of connectivity in underlying cognitive performance generally and abnormal global topology underlying discrete cognitive impairments in BD.en_IE
dc.description.sponsorshipWe gratefully acknowledge the participants, the support of the Welcome-Trust HRB Clinical Research Facility, the Centre for Advanced Medical Imaging at St. James Hospital Dublin and funding support from the Irish Research Council Government of Ireland Postgraduate Scholarship. We would also like to thank Andrew Hoopes, Research Technician I, MGH/HST Martinos Center for Biomedical Imaging for Freesurfer software support, Christopher Grogan, MSc, for his contribution to data processing and Jenna Pittman, BSc and Fiona Martyn, BA for their contribution to data handling. This research was funded by the Health Research Board (HRA-POR324) awarded to Dara M. Cannon, PhD.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofBiological Psychiatry-Cognitive Neuroscience And Neuroimagingen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectBipolar disorderen_IE
dc.subjectCognitionen_IE
dc.subjectDiffusion magnetic resonance imagingen_IE
dc.subjectGraph theoryen_IE
dc.subjectNetwork analysisen_IE
dc.subjectRich cluben_IE
dc.subjectSTRUCTURAL BRAIN NETWORKSen_IE
dc.subjectWHITE-MATTER INTEGRITYen_IE
dc.subjectEUTHYMIC PATIENTSen_IE
dc.subjectMETAANALYSISen_IE
dc.subjectCONNECTIVITYen_IE
dc.subjectIMPAIRMENTen_IE
dc.subjectSCHIZOPHRENIAen_IE
dc.subjectINTEGRATIONen_IE
dc.subjectPERFORMANCEen_IE
dc.subjectABNORMALITIESen_IE
dc.titleNeuroanatomical dysconnectivity underlying cognitive deficits in bipolar disorderen_IE
dc.typeArticleen_IE
dc.date.updated2020-06-04T20:19:12Z
dc.identifier.doi10.1016/j.bpsc.2019.09.004
dc.local.publishedsourcehttps://doi.org/10.1016/j.bpsc.2019.09.004en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderHealth Research Boarden_IE
dc.description.embargo2020-09-18
dc.internal.rssid20047247
dc.local.contactDara Cannon, 1024 Human Biology Building, University Road, Nui Galway, Co Galway. 5692 Email: dara.cannon@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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