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dc.contributor.authorMorris, Cheryl
dc.contributor.authorRyder, Alan G.
dc.date.accessioned2020-03-12T11:21:53Z
dc.date.available2020-03-12T11:21:53Z
dc.date.issued2015-12-18
dc.identifier.citationMorris, Cheryl, & Ryder, Alan G. (2016). Fluorescence Analysis of Thermoresponsive Polymers. In Chris D. Geddes (Ed.), Reviews in Fluorescence 2015 (pp. 97-126). Cham: Springer International Publishing.en_IE
dc.identifier.isbn978-3-319-24607-9
dc.identifier.isbn978-3-319-24609-3
dc.identifier.urihttp://hdl.handle.net/10379/15844
dc.description.abstractThe use of microscale thin polymer films is widespread in biomedical science and engineering, with applications in areas such as tissue engineering, drug delivery, microfluidic devices, bio-adhesion mediators, and bio-actuators. Much attention is devoted to the use of functional polymers that display stimuliresponsive behavior with the intention of providing "smart" coatings. One potential example is the use of thin thermoresponsive polymer films as drug eluting coatings on medical devices, where not only does the polymer function as a drug reservoir but it also acts as a biocompatibility modulator to improve device performance.Often these thin polymer coatings have to be applied to complex geometries, which can cause problems for in-situ analysis. Another important consideration is the fact that these films have large surface area to mass ratios and thus water uptake can be significant. This is serious because coating stability, device efficacy, and long-term storage are influenced by the physiochemical properties of the polymer which are modulated by water content. Thus, there is a need for a rapid, non-contact, non-destructive, analytical method capable of analyzing thermoresponsive polymers in solution, and in-situ of the solid-state on medical devices. Fluorescence spectroscopy based methods can deal with both sample types and provide additional benefits in terms of high sensitivity and low probe concentrations, which provide for minimal sample disruption. This article gives a brief overview of the application of various fluorescence methods for the physicochemical characterization of thermoresponsive polymers such as poly (N-isopropylacrylamide), PNIPAm.en_IE
dc.description.sponsorshipThe preparation of this work was supported by Science Foundation Ireland under a Research Frontiers Grant 07/RFP/MASF423 to A.G.R.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherSpringer Verlagen_IE
dc.relation.ispartofReviews In Fluorescence 2015en
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectHYDROPHOBICALLY-MODIFIED POLY(N-ISOPROPYLACRYLAMIDES)en_IE
dc.subjectSOLVATOCHROMIC COMPARISON METHODen_IE
dc.subjectINTRAMOLECULAR PROTON-TRANSFERen_IE
dc.subjectTIME-RESOLVED FLUORESCENCEen_IE
dc.subjectDILUTE AQUEOUS-SOLUTIONSen_IE
dc.subjectN-ISOPROPYLACRYLAMIDEen_IE
dc.subjectCORRELATION SPECTROSCOPYen_IE
dc.subjectAGGREGATION BEHAVIORen_IE
dc.subjectSOLVENT POLARITIESen_IE
dc.subjectDELIVERY-SYSTEMSen_IE
dc.titleFluorescence analysis of thermoresponsive polymersen_IE
dc.typeBook chapteren_IE
dc.date.updated2020-03-11T14:59:50Z
dc.identifier.doi10.1007/978-3-319-24609-3_4
dc.local.publishedsourcehttps://doi.org/10.1007/978-3-319-24609-3_4en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.internal.rssid16216056
dc.local.contactAlan Ryder, School Of Chemistry, Room 213, Arts/Science Building, South Cam, Nui Galway. 2943 Email: alan.ryder@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Frontiers Programme (RFP)/07/RFP/MASF423/IE/Quantitative non-contact measurements of the physicochemical properties of biomedical polymers using advanced fluorescence methods: replacing the contact angle method./en_IE
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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