Show simple item record

dc.contributor.authorDevadasan, Carol
dc.contributor.authorStarr, Beryl
dc.contributor.authorDoyle, Karen M.
dc.date.accessioned2020-01-24T12:48:27Z
dc.date.available2020-01-24T12:48:27Z
dc.date.issued2016-09-01
dc.identifier.citationDevadasan, Carol, Starr, Beryl, & Doyle, Karen M. (2016). Effect of N1-dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the reserpinized mouse model of Parkinson’s disease. NeuroReport, 27(17), 1243-1247. doi: 10.1097/wnr.0000000000000685en_IE
dc.identifier.issn1473-558X
dc.identifier.urihttp://hdl.handle.net/10379/15736
dc.description.abstractThe effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor activity in naive mice was investigated. Furthermore, the ability of the polyamine antagonists to reverse reserpine-induced hypokinesia was assessed, 24 h after injection of a catecholamine-depleting dose of reserpine (5 mg/kg, subcutaneous), to investigate the therapeutic potential of polyamine antagonists in Parkinson’s disease. N1-dansylspermine significantly decreased locomotor activity in naive animals (P<0.001) but caused a mild, but significant increase in locomotor activity in reserpinized mice at the highest dose tested (P<0.05). Ro25,6981 significantly stimulated locomotor activity in naive animals (P<0.001) and had a slight significant stimulatory effect on reserpine-induced hypokinesia (P=0.05). N1-dansylspermine and Ro25,6981 had opposite effects on locomotor activity in naive mice, but both had a mild antiparkinsonian effect in the reserpine model. These findings suggest that antagonism of the polyamine binding site on the GluN2B subunit can reduce hypokinesia, albeit to a limited extent.en_IE
dc.description.sponsorshipThis study was supported by a postgraduate Scholarship from University of Hertfordshire and the kind provision of N1-acetylspermine by Prof. Graham Shaw, School of Pharmacy, Trinity College, Dublin.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherLippincott, Williams & Wilkinsen_IE
dc.relation.ispartofNeuroreporten
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectGluN2B antagonisten_IE
dc.subjectlocomotor activityen_IE
dc.subjectN1-dansylspermineen_IE
dc.subjectParkinson’s diseaseen_IE
dc.subjectpolyamine antagonisten_IE
dc.subjectreserpine mouse modelen_IE
dc.subjectRo25,6981en_IE
dc.titleEffect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's diseaseen_IE
dc.typeArticleen_IE
dc.date.updated2020-01-24T09:21:27Z
dc.identifier.doi10.1097/WNR.0000000000000685
dc.local.publishedsourcehttps://dx.doi.org/10.1097/WNR.0000000000000685en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderUniversity of Hertfordshireen_IE
dc.internal.rssid12735669
dc.local.contactKaren Doyle, Dept. Of Physiology, Human Biology Building, Nui Galway. 3665 Email: karen.doyle@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
nui.item.downloads140


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland