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dc.contributor.authorMoreira da Silva Santos, Andreia
dc.contributor.authorKelly, John P.
dc.contributor.authorDoyle, Karen M.
dc.date.accessioned2020-01-24T11:33:57Z
dc.date.available2020-01-24T11:33:57Z
dc.date.issued2017-10-24
dc.identifier.citationMoreira da Silva Santos, A., Kelly, J. P., & Doyle, K. M. (2017). Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain. Neuropsychobiology, 75(2), 63-71. doi: 10.1159/000480513en_IE
dc.identifier.issn1423-0224
dc.identifier.urihttp://hdl.handle.net/10379/15734
dc.description.abstractThis study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h of observation. A significant increase in dopamine concentration was observed in the frontal cortex with the highest dose of methamphetamine (2 h after the last dose). This effect was dose- and region-specific, as no significant increase was observed with lower doses, nor was a significant change observed in any other brain region tested. A similar dose- and region-specific increase in brain-derived neurotrophic factor (BDNF) was observed in the frontal cortex with the highest-dose regimen. No significant change occurred with lower doses of methamphetamine, or in any other brain region tested. A reduction in BDNF levels in the serum was also observed with the highest concentration, but not with lower doses. Collectively, this data highlights the importance of the frontal cortex in methamphetamine-induced effects, and also the similar dose-response effect of methamphetamine on dopamine and BDNF expression.en_IE
dc.description.sponsorshipThis research was funded by a College of Science Scholarship, National University of Ireland, Galway, Ireland.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherKarger Publishersen_IE
dc.relation.ispartofNeuropsychobiologyen
dc.subjectMethamphetamineen_IE
dc.subjectDose-dependent responseen_IE
dc.subjectDopamineen_IE
dc.subjectNeurotrophinen_IE
dc.subjectBrain-derived neurotrophic factoren_IE
dc.subjectFrontal cortexen_IE
dc.titleDose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brainen_IE
dc.typeArticleen_IE
dc.date.updated2020-01-24T09:18:56Z
dc.identifier.doi10.1159/000480513
dc.local.publishedsourcehttps://doi.org/10.1159/000480513en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderCollege of Science, National University of Ireland, Galwayen_IE
dc.internal.rssid13518666
dc.local.contactKaren Doyle, Dept. Of Physiology, Human Biology Building, Nui Galway. 3665 Email: karen.doyle@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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