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dc.contributor.authorGoertz, Sarah
dc.contributor.authorde Menezes, Alexandre B.
dc.contributor.authorBirtles, Richard J.
dc.contributor.authorFenn, Jonathan
dc.contributor.authorLowe, Ann E.
dc.contributor.authorMacColl, Andrew D. C.
dc.contributor.authorPoulin, Benoit
dc.contributor.authorYoung, Stuart
dc.contributor.authorBradley, Janette E.
dc.contributor.authorTaylor, Christopher H.
dc.date.accessioned2020-01-21T11:02:37Z
dc.date.available2020-01-21T11:02:37Z
dc.date.issued2019-09-26
dc.identifier.citationGoertz S, de Menezes AB, Birtles RJ, Fenn J, Lowe AE, MacColl ADC, et al. (2019) Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale. PLoS ONE 14(9): e0222501. https://doi.org/10.1371/journal.pone.0222501en_IE
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10379/15717
dc.description.abstractThe composition of the mammalian gut microbiota can be influenced by a multitude of environmental variables such as diet and infections. Studies investigating the effect of these variables on gut microbiota composition often sample across multiple separate populations and habitat types. In this study we explore how variation in the gut microbiota of the house mouse (Mus musculus domesticus) on the Isle of May, a small island off the east coast of Scotland, is associated with environmental and biological factors. Our study focuses on the effects of environmental variables, specifically trapping location and surrounding vegetation, as well as the host variables sex, age, body weight and endoparasite infection, on the gut microbiota composition across a fine spatial scale in a freely interbreeding population. We found that differences in gut microbiota composition were significantly associated with the trapping location of the host, even across this small spatial scale. Sex of the host showed a weak association with microbiota composition. Whilst sex and location could be identified as playing an important role in the compositional variation of the gut microbiota, 75% of the variation remains unexplained. Whereas other rodent studies have found associations between gut microbiota composition and age of the host or parasite infections, the present study could not clearly establish these associations. We conclude that fine spatial scales are important when considering gut microbiota composition and investigating differences among individuals.en_IE
dc.description.sponsorshipThis work was supported by The Natural Environment Research Council (NERC) [grant number NE/L002604/1] as part of the Envision Doctoral Training Programme studentship (URL: https://nerc.ukri.org/) which was awarded to SG. This work was also supported by the Biotechnology and Biological Sciences Research Council [grant number BB/J014508/1], a Doctoral Training Programme studentship (URL: https://bbsrc.ukri.org/) awarded to SY and JF. The funders did not play any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherPublic Library of Scienceen_IE
dc.relation.ispartofPlos Oneen
dc.subjectGeographical locationen_IE
dc.subjectgut microbiotaen_IE
dc.subjectwild house miceen_IE
dc.subjectMus musculus domesticusen_IE
dc.titleGeographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scaleen_IE
dc.typeArticleen_IE
dc.date.updated2020-01-21T09:37:45Z
dc.identifier.doi10.1371/journal.pone.0222501
dc.local.publishedsourcehttps://doi.org/10.1371/journal.pone.0222501en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderNatural Environment Research Councilen_IE
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_IE
dc.internal.rssid18715073
dc.local.contactAlexandre De Menezes, Room Es106, Microbiology, Arts And Science Building, School Of Natural Sciences, Ryan Institute. - Email: alexandre.demenezes@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/RCUK/NERC/NE/L002604/1/GB/ENVISION: Developing next generation leaders in environmental science/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/RCUK/BBSRC/BB/J014508/1/GB/BB/J014508/1/en_IE
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