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dc.contributor.authorBurke, Nikita N.
dc.contributor.authorCoppinger, Jonathan
dc.contributor.authorDeaver, Daniel R.
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.contributor.authorKelly, John
dc.date.accessioned2020-01-13T14:11:30Z
dc.date.available2020-01-13T14:11:30Z
dc.date.issued2016-08-31
dc.identifier.citationBurke, Nikita N., Coppinger, Jonathan, Deaver, Daniel R., Roche, Michelle, Finn, David P., & Kelly, John. (2016). Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat. Physiology & Behavior, 167, 28-34. doi: https://doi.org/10.1016/j.physbeh.2016.08.031en_IE
dc.identifier.issn1873-507X
dc.identifier.urihttp://hdl.handle.net/10379/15700
dc.description.abstractDepression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress hyper-responsive Wistar-Kyoto (WKY) rat displays hypolocotnotion in a novel aversive environment and depressive and anxiety-like behaviours, which have been mostly characterised in males. The current study characterised behaviour in male and female rats in a battery of behavioural paradigms. Adult male and female WKY rats were tested in the open field and forced swim tests (tests with a locomotor component); and the marble burying, novelty induced hypophagia and sucrose preference tests (tests with a minimal locomotor component) and 24 h home-cage locomotor activity was also monitored. The tests were compared against the Sprague-Dawley (SD) strain, a commonly used "control" strain.SD, but not WKY, females exhibited higher home-cage locomotor activity-compared to males. In the open field, WKY rats of both sexes exhibited a significant reduction in locomotor activity and increased anxiety-like behaviour as demonstrated by reduced time in the aversive inner zone of the open field, compared to SD counterparts. In the marble burying test, WKY females, but not males, exhibited a trend towards increased burying, indicative of anxiety-like/neophobic behaviour. In comparison, WKY males, but not females, exhibited enhanced novelty induced hypophagia, indicative of increased anxiety-like behaviour compared to SD rats. In the forced swim test, WKY rats of both sexes spent more time immobile compared with SD counterparts, indicating depressive-like behaviour. However, in comparison to SD rats, WKY males, but not females, exhibited anhedonic-like behaviour. In conclusion, WKY rats exhibit depressive-and anxiety-like behaviours that are complex and nuanced depending on the sex of the rat and testing conditions. This study supports the use of a varied test battery to fully characterise depression/anxiety-like behaviour in male and female rats. (C) 2016 Elsevier Inc. All rights reserved.en_IE
dc.description.sponsorshipThis study was supported by an Industry-Academia collaboration with funding provided by Alkermes (RIN997). Financial sponsors had no role in the study design, collection, analysis or interpretation of data.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofPhysiology & Behavioren
dc.subjectDepressionen_IE
dc.subjectAnxietyen_IE
dc.subjectSexen_IE
dc.subjectWistar-Kyotoen_IE
dc.subjectSprague-Dawleyen_IE
dc.subjectSWEDISH NATIONAL TWINen_IE
dc.subjectSPRAGUE-DAWLEY RATSen_IE
dc.subjectELEVATED PLUS-MAZEen_IE
dc.subjectWKY RATSen_IE
dc.subjectMAJOR DEPRESSIONen_IE
dc.subjectMOOD DISORDERSen_IE
dc.subjectANIMAL-MODELSen_IE
dc.subjectSTRESS-ULCERen_IE
dc.subjectGENDER-DIFFERENCESen_IE
dc.subjectCO-MORBIDITYen_IE
dc.titleSex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto raten_IE
dc.typeArticleen_IE
dc.date.updated2020-01-13T11:16:08Z
dc.identifier.doi10.1016/j.physbeh.2016.08.031
dc.local.publishedsourcehttps://doi.org/10.1016/j.physbeh.2016.08.031en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderAlkermes Incen_IE
dc.internal.rssid11779289
dc.local.contactMichelle Roche, Physiology, Rm2002 Human Biology Building, National University Of Ireland G, University Road. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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