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dc.contributor.authorHenry, Rebecca J.
dc.contributor.authorKerr, Daniel M.
dc.contributor.authorFinn, David P.
dc.contributor.authorRoche, Michelle
dc.date.accessioned2020-01-13T10:54:46Z
dc.date.available2020-01-13T10:54:46Z
dc.date.issued2015-03-17
dc.identifier.citationHenry, Rebecca J., Kerr, Daniel M., Finn, David P., & Roche, Michelle. (2016). For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 64, 167-180. doi: https://doi.org/10.1016/j.pnpbp.2015.03.006en_IE
dc.identifier.issn1878-4216
dc.identifier.urihttp://hdl.handle.net/10379/15694
dc.description.abstractToll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects on neurotransmission and neurodegenerative cascades and has been proposed to trigger the onset of certain neurodegenerative disorders and elicit detrimental effects on the progression and outcome of established disease. Over the past decade, there has been increasing evidence demonstrating that the endocannabinoid system can elicit potent modulatory effects on inflammatory processes, with clinical and preclinical evidence demonstrating beneficial effects on disease severity and symptoms in several inflammatory conditions. This review examines the evidence supporting a modulatory effect of endocannabinoids on TLR-mediated immune responses both peripherally and centrally, and the implications for psychiatric disorders such as depression and schizophrenia. (C) 2015 Elsevier Inc. All rights reserved.en_IE
dc.description.sponsorshipThe authors would like to gratefully acknowledge funding received from the Science Foundation Ireland Research Frontiers Programme (Grant no. 11/RFP/NES/3175). The authors declare no conflict of interest.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatryen
dc.subject2-AGen_IE
dc.subjectAnandamideen_IE
dc.subjectDepressionen_IE
dc.subjectLPSen_IE
dc.subjectPoly I:Cen_IE
dc.subjectSchizophreniaen_IE
dc.subjectCANNABINOID CB2 RECEPTORSen_IE
dc.subjectMURINE ENCEPHALOMYELITIS VIRUSen_IE
dc.subjectINDUCED SICKNESS BEHAVIORen_IE
dc.subjectMESSENGER-RNA EXPRESSIONen_IE
dc.subjectN-ARACHIDONOYL DOPAMINEen_IE
dc.subjectANXIETY-LIKE BEHAVIORSen_IE
dc.subjectRAT MICROGLIAL CELLSen_IE
dc.subjectNITRIC-OXIDEen_IE
dc.subjectTHEILERS VIRUSen_IE
dc.subjectTNF-ALPHAen_IE
dc.titleFor whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disordersen_IE
dc.typeArticleen_IE
dc.date.updated2020-01-10T10:22:45Z
dc.identifier.doi10.1016/j.pnpbp.2015.03.006
dc.local.publishedsourcehttps://doi.org/10.1016/j.pnpbp.2015.03.006en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.internal.rssid9874508
dc.local.contactMichelle Roche, Physiology, Rm2002 Human Biology Building, National University Of Ireland G, University Road. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Frontiers Programme (RFP)/11/RFP.1/NES/3175/IE/Endocannabinoid regulation of neuroinflammatory responses following bacterial and viral infection/en_IE
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