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dc.contributor.authorFitzgibbon, Marie
dc.contributor.authorFinn, David P.
dc.contributor.authorRoche, Michelle
dc.date.accessioned2020-01-13T09:57:11Z
dc.date.available2020-01-13T09:57:11Z
dc.date.issued2015-09-05
dc.identifier.citationFitzgibbon, Marie, Finn, David P., & Roche, Michelle. (2015). High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity. International Journal of Neuropsychopharmacology, 19(3). doi: 10.1093/ijnp/pyv095en_IE
dc.identifier.issn1469-5111
dc.identifier.urihttp://hdl.handle.net/10379/15692
dc.description.abstractDepression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability and impaired health-related quality of life than either condition alone, resulting in enormous social and economic cost. Several neural substrates have been identified as potential mediators in the association between depression and pain, including neuroanatomical reorganization, monoamine and neurotrophin depletion, dysregulation of the hypothalamo-pituitary-adrenal axis, and neuroinflammation. However, the past decade has seen mounting evidence supporting a role for the endogenous cannabinoid (endocannabinoid) system in affective and nociceptive processing, and thus, alterations in this system may play a key role in reciprocal interactions between depression and pain. This review will provide an overview of the preclinical evidence supporting an interaction between depression and pain and the evidence supporting a role for the endocannabinoid system in this interaction.en_IE
dc.description.sponsorshipThis work was supported by funding received from Molecular Medicine Ireland Clinical & Translational Research Scholars Programme.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherOxford University Press (OUP)en_IE
dc.relation.ispartofInternational Journal Of Neuropsychopharmacologyen
dc.subjectdepressionen_IE
dc.subjectpainen_IE
dc.subjectanandamideen_IE
dc.subjectcannabinoiden_IE
dc.subjectstressen_IE
dc.titleHigh times for painful blues: the endocannabinoid system in pain-depression comorbidityen_IE
dc.typeArticleen_IE
dc.date.updated2020-01-10T10:01:24Z
dc.identifier.doi10.1093/ijnp/pyv095
dc.local.publishedsourcehttps://doi.org/10.1093/ijnp/pyv095en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderMolecular Medicine Ireland Clinical & Translational Research Scholars Programmeen_IE
dc.internal.rssid10575299
dc.local.contactMichelle Roche, Physiology, Rm2002 Human Biology Building, National University Of Ireland G, University Road. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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