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Label free ultra-sensitive imaging with sub-diffraction spatial resolution

dc.contributor.authorAlexandrov, Sergey
dc.contributor.authorDas, Nandan
dc.contributor.authorMcGrath, James
dc.contributor.authorOwens, Peter
dc.contributor.authorSheppard, Colin J. R.
dc.contributor.authorBoccafoschi, Francesca
dc.contributor.authorGiannini, Cinzia
dc.contributor.authorSibillano, Teresa
dc.contributor.authorSubhash, Hrebesh
dc.contributor.authorLeahy, Martin
dc.date.accessioned2019-09-24T10:58:40Z
dc.date.available2019-09-24T10:58:40Z
dc.date.issued2019-07-09
dc.identifier.citationAlexandrov, Sergey, Das, Nandan, McGrath, James, Owens, Peter, Sheppard, Colin J. R., Boccafoschi, Francesca, Giannini, Cinzia, Sibillano, Teresa, Subhash, Hrebesh, Leahy, Martin. (2019). Label free ultra-sensitive imaging with sub-diffraction spatial resolution. Paper presented at the 21st International Conference on Transparent Optical Networks, ICTON’2019, Angers, France, 09-13 July.en_IE
dc.identifier.urihttp://hdl.handle.net/10379/15458
dc.description.abstractIn this paper, we show a new way to break the resolution limit and dramatically improve sensitivity to structural changes. To realize it we developed a novel label free contrast mechanism, based on the spectral encoding of spatial frequency (SESF) approach. The super-resolution SESF (srSESF) microscopy is based on reconstruction of the axial spatial frequency (period) profiles for each image point and comparison of these profiles to form super-resolution image. As a result, the information content of images is dramatically improved in comparison with conventional microscopy. Numerical simulation and experiments demonstrate significant improvement in sensitivity and resolution.en_IE
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 761214. The materials presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out. Also, this work was supported by NUI Galway, Galway University Foundation, and the National Biophotonics Imaging Platform (NBIP) Ireland and Gov. of Ireland Postdoctoral fellowship-2017 to Nandan Das.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherIEEEen_IE
dc.relation.ispartofICTON 2019en
dc.subjectoptical microscopyen_IE
dc.subjectlabel free imagingen_IE
dc.subjectnano-sensitivityen_IE
dc.subjectsuper-resolutionen_IE
dc.subjectspatial frequencyen_IE
dc.subjectSpatial resolutionen_IE
dc.subjectMicroscopyen_IE
dc.subjectOptical microscopyen_IE
dc.subjectOptical imagingen_IE
dc.subjectOptical diffractionen_IE
dc.titleLabel free ultra-sensitive imaging with sub-diffraction spatial resolutionen_IE
dc.typeConference Paperen_IE
dc.date.updated2019-09-23T16:21:10Z
dc.identifier.doi10.1109/ICTON.2019.8840220
dc.local.publishedsourcehttps://dx.doi.org/10.1109/ICTON.2019.8840220en_IE
dc.description.peer-reviewednon-peer-reviewed
dc.contributor.funderHorizon 2020en_IE
dc.contributor.funderGalway University Foundationen_IE
dc.contributor.funderIrish Research Councilen_IE
dc.internal.rssid17767881
dc.local.contactSergey Alexandrov, School Of Physics, Nui Galway. - Email: sergey.alexandrov@nuigalway.ie
dc.local.copyrightcheckedYes
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/761214/EU/NanoSTARS imaging for STEM cell therapy for arthritic joints/STARSTEMen_IE
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