Show simple item record

dc.contributor.authorGanter, Niamh M.
dc.contributor.authorTong, Kezanne
dc.contributor.authorMcDonald, Colm
dc.contributor.authorDoherty, Anne M.
dc.date.accessioned2019-09-05T10:55:59Z
dc.date.issued2019-01-10
dc.identifier.citationGanter, Niamh M., Tong, Kezanne, McDonald, Colm, & Doherty, Anne M. (2019). The clinical characteristics and correlates of lithium toxicity in a tertiary referral centre. Irish Journal of Medical Science, 188(3), 1103-1109. doi: 10.1007/s11845-018-01963-9en_IE
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.urihttp://hdl.handle.net/10379/15402
dc.description.abstractIntroduction Lithium is a medication indicated for the treatment of bipolar disorder and treatment-resistant depression, with a narrow therapeutic index. Overdose, either acute or chronic can result in neurological symptoms, requiring dialysis and admission to intensive care in some cases. Lithium toxicity is avoidable with careful monitoring. However, we have noted several recent cases of lithium toxicity in our local service and thus sought to investigate this issue in a more systematic manner.Aim We aimed to quantify the incidence of lithium toxicity in our local population over a single year and identify the patients most at risk. We also aimed to generate clinical recommendations on the prevention of lithium toxicity to improve patient safety.Method We identified the incidence of lithium toxicity in our local population, by searching the hospital pathology database for patients with serum lithium levels greater than 1.0 mmol/L. We examined the available clinical notes for these patients.Results We identified 74 serum lithium readings above 1.0 mmol/L measured in 44 individual patients. The highest recorded level was 3.2 mmol/L. Of these, 11 patients were aged 65years or older. Hospital admission was required in 14 cases. There were missing data of note: 29.5% had no renal function/eGFR measurement at time of toxicity and 52.3% without a baseline eGFR.Conclusion Lithium toxicity is common in our population. Given the narrow therapeutic index, this demonstrates the need for careful monitoring and prescribing, especially patients aged 65 and over.en_IE
dc.description.sponsorshipGrant supplied by Undergraduate Research Committee, School of Medicine, National University of Ireland, Galway.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherSpringer Verlagen_IE
dc.relation.ispartofIrish Journal of Medical Scienceen
dc.subjectINTOXICATIONen_IE
dc.subjectlithiumen_IE
dc.subjecttoxicityen_IE
dc.titleThe clinical characteristics and correlates of lithium toxicity in a tertiary referral centreen_IE
dc.typeArticleen_IE
dc.date.updated2019-08-26T12:56:23Z
dc.identifier.doi10.1007/s11845-018-01963-9
dc.local.publishedsourcehttps://doi.org/10.1007/s11845-018-01963-9en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderSchool of Medicine, National University of Ireland Galway.en_IE
dc.description.embargo2020-01-10
dc.internal.rssid17115269
dc.local.contactAnne Doherty, School Of Medicine, Nui Galway. Email: anne.doherty@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
nui.item.downloads1


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record