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dc.contributor.authorPotter, Shirley M.
dc.contributor.authorDwyer, Róisín M.
dc.contributor.authorCurran, Catherine E.
dc.contributor.authorHennessy, Emer
dc.contributor.authorHarrington, Kate A.
dc.contributor.authorGriffin, Damian G.
dc.contributor.authorKerin, Michael J.
dc.date.accessioned2019-09-04T11:37:56Z
dc.date.available2019-09-04T11:37:56Z
dc.date.issued2008-06-04
dc.identifier.citationPotter, Shirley M., Dwyer, Roisin M., Curran, Catherine E., Hennessy, Emer, Harrington, Kate A., Griffin, Damian G., & Kerin, Michael J. (2009). Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones. Breast Cancer Research and Treatment, 115(2), 279-287. doi: 10.1007/s10549-008-0078-2en_IE
dc.identifier.issn1573-7217
dc.identifier.urihttp://hdl.handle.net/10379/15388
dc.description.abstractIntroduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic MCP-1 in breast cancer patients. This study investigated circulating levels of SDF-1 alpha in breast cancer patients, and addressed potential hormonal regulation of these two potent chemokines. Methods SDF-1 alpha levels were determined by ELISA in 114 breast cancer patients and 85 controls, and correlated with clinical data. Blood samples were collected from 36 healthy premenopausal volunteers weekly for four weeks to measure Luteinising Hormone (LH), Follicular Stimulating Hormone (FSH), Oestradiol and Progesterone using a Bayer ADVIA(A (R)) Centaur Immunoassay system, in parallel with SDF-1 alpha and MCP-1. CXCL12 expression was determined using RQ-PCR in primary tumour stromal cells (n = 16) harvested at surgery. Results Plasma SDF-1 alpha was significantly higher in breast cancer patients than age-matched controls and had a significant correlation with tumour grade and epithelial subtype. Investigation of menstrual variations of these chemokines revealed lower SDF-1 alpha levels in the mid-luteal phase of the menstrual cycle and a significant positive correlation with circulating Oestradiol. MCP-1 levels showed no correlation with menstrual hormones. There was a trend towards increased CXCL12 expression in tumour compared to normal stromal cells. Conclusions The elevated level of SDF-1 alpha detected in breast cancer patients, and it's correlation with prognostic indicators, highlights the importance of this chemokine in disease progression. Elucidation of factors influencing chemokine secretion supports clarification of their role in tumourigenesis.en_IE
dc.description.sponsorshipThe National Breast Cancer Research Institute (NBCRI) provided the main source of funding for this work. RM Dwyer is also supported by a Health Research Board of Ireland Postdoctoral Fellowship. We are grateful to Dr. John Newell for advice relating to statistical analysis.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherSpringeren_IE
dc.relation.ispartofBreast Cancer Research And Treatmenten
dc.subjectBreast canceren_IE
dc.subjectMenstrual hormonesen_IE
dc.subjectMonocyte Chemotactic Protein-1 (MCP-1/CCL2)en_IE
dc.subjectPrognosisen_IE
dc.subjectStromal Cell-derived Factor 1-alpha (SDF-1 alpha/CXCL12)en_IE
dc.subjectSTROMAL-DERIVED FACTOR-1-ALPHAen_IE
dc.subjectTUMOR-MICROENVIRONMENTen_IE
dc.subjectPREMENOPAUSAL WOMENen_IE
dc.subjectMULTIPLE-MYELOMAen_IE
dc.subjectPLASMA-LEVELSen_IE
dc.subjectSERUM-LEVELSen_IE
dc.subjectCELLSen_IE
dc.subjectPROGRESSIONen_IE
dc.subjectMETASTASISen_IE
dc.subjectRECEPTORen_IE
dc.titleSystemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormonesen_IE
dc.date.updated2019-08-16T10:19:11Z
dc.identifier.doi10.1007/s10549-008-0078-2
dc.local.publishedsourcehttps://doi.org/10.1007/s10549-008-0078-2en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderNational Breast Cancer Research Instituteen_IE
dc.contributor.funderHealth Research Boarden_IE
dc.internal.rssid1338793
dc.local.contactRóisín Dwyer, Surgery, Nui Galway. 3008 Email: roisin.dwyer@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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