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dc.contributor.authorBree, Dara
dc.contributor.authorMoriarty, Orla
dc.contributor.authorO’Mahony, Cliona M.
dc.contributor.authorMorris, Bradley
dc.contributor.authorBannerton, Karen
dc.contributor.authorBroom, Daniel C.
dc.contributor.authorKelly, John P.
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2019-08-30T09:10:52Z
dc.date.available2019-08-30T09:10:52Z
dc.date.issued2015-01-30
dc.identifier.citationBree, D,Moriarty, O,Mahony, CM,Morris, B,Bannerton, K,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, 16 :421-435.en_IE
dc.identifier.issn1528-8447
dc.identifier.urihttp://hdl.handle.net/10379/15365
dc.description.abstractAcute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved predictive validity, would advance understanding of postoperative pain mechanisms and improve treatment outcomes. This study aimed to develop, characterize, and validate a rat model of acute postoperative pain associated with inguinal hernia repair based on the Lichtenstein inguinal hernia repair procedure (without hernia induction). We hypothesized that the surgery would result in reduced spontaneous locomotor activity, which would represent a pain-related phenotype. Postsurgical characterization involved extensive monitoring of home cage and open field locomotor activity, as well as mechanical hypersensitivity and assessment of c-Fos expression in the dorsal horn of the spinal cord. In pharmacologic validation studies, rats received morphine, carprofen, or paracetamol 1 hour before, and/or immediately after, surgery. Rats that underwent hernia repair surgery exhibited significantly lower horizontal and vertical activities in the home cage and open field in the early postsurgical period, compared with sham rats or rats that underwent skin incision only. Morphine, carprofen, and paracetamol attenuated the surgery-induced reductions in locomotor activity, to varying degrees. Surgery was associated with significantly increased c-Fos expression in the ipsilateral dorsal horn of the spinal cord, an effect attenuated by carprofen treatment. These results support the development and characterization of a novel, anatomically relevant animal model of acute postoperative pain that may facilitate development of improved treatment regimens.Perspective: Acute pain following inguinal hernia repair can be difficult to treat. Here we report, for the first time, the development of a novel, anatomically relevant rat model to facilitate improved understanding and treatment of acute postoperative pain following inguinal hernia repair. (C) 2015 by the American Pain Societyen_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofJournal Of Painen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectPostsurgical painen_IE
dc.subjecthernia repairen_IE
dc.subjectmorphineen_IE
dc.subjectcarprofenen_IE
dc.subjectparacetamolen_IE
dc.subjectlocomotor activityen_IE
dc.subjectbehavioren_IE
dc.subjectc-Fosen_IE
dc.subjectINGUINAL-HERNIASen_IE
dc.subjectANALGESICSen_IE
dc.subjectCARPROFENen_IE
dc.subjectSURGERYen_IE
dc.subjectLAPAROTOMYen_IE
dc.subjectREDUCTIONen_IE
dc.subjectALLODYNIAen_IE
dc.subjectINCISIONen_IE
dc.subjectBEHAVIORen_IE
dc.subjectNERVEen_IE
dc.titleDevelopment and characterization of a novel, anatomically relevant rat model of acute postoperative painen_IE
dc.typeArticleen_IE
dc.date.updated2016-04-22T15:51:28Z
dc.identifier.doi10.1016/j.jpain.2015.01.010
dc.local.publishedsourcehttps://doi.org/10.1016/j.jpain.2015.01.010en_IE
dc.description.peer-reviewedpeer-reviewed
dc.internal.rssid8983057
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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