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dc.contributor.authorBreen, Bridget A.
dc.contributor.authorKraskiewicz, Honorata
dc.contributor.authorRonan, Rachel
dc.contributor.authorKshiragar, Aniket
dc.contributor.authorPatar, Azim
dc.contributor.authorSargeant, Timothy
dc.contributor.authorPandit, Abhay
dc.contributor.authorMcMahon, Siobhan S.
dc.date.accessioned2019-08-19T13:54:14Z
dc.date.available2019-08-19T13:54:14Z
dc.date.issued2016-08-01
dc.identifier.citationBreen, Bridget A., Kraskiewicz, Honorata, Ronan, Rachel, Kshiragar, Aniket, Patar, Azim, Sargeant, Timothy, Pandit, Abhay, McMahon, Siobhan S. (2017). Therapeutic Effect of Neurotrophin-3 Treatment in an Injectable Collagen Scaffold Following Rat Spinal Cord Hemisection Injury. ACS Biomaterials Science & Engineering, 3(7), 1287-1295. doi: 10.1021/acsbiomaterials.6b00167en_IE
dc.identifier.issn2373-9878
dc.identifier.urihttp://hdl.handle.net/10379/15319
dc.description.abstractSpinal cord injury (SCI) patients display varying quantities of spinal cord tissue damage with injuries that present as complete, incomplete or compressive. One theory proposed to repair the injured spinal cord and regain motor control is to regenerate axons through the lesion site. This study was designed to quantify the impact of a local injectable in situ forming hydrogel reservoir therapy following rat hemisection SCI. We investigated the effect of hydrogel only treatment following SCI in addition to hydrogels loaded with a neurotrophic factor, Neurotrophin-3 (NT-3), immediately following SCI. Functional recovery, assessed by Basso Beattie Bresnahan (BBB) locomotor test, and local healing mechanisms, including neuronal growth, glial scar formation, inflammation and collagen deposition were investigated one and 6 weeks postsurgery. Delivery of an injectable hydrogel significantly increased functional recovery at four and 6 weeks post injury. In addition, a significant reduction in the inhibitory glial scar and in inflammation was observed at the injury site. Similarly hydrogel + NT-3 delivered directly into the injury site significantly reduced glial scarring and collagen deposition. The hydrogel + NT-3 also resulted in a significant increase in neurons at 6 weeks post injury. This study represents a novel and effective therapy combining growth factor and a biomaterial based therapy following SCI.en_IE
dc.description.sponsorshipB.B. and H.K. were supported by Covidien LLC and the Industrial Development Agency (IDA) of Ireland grant. R.R. and A.K. supported by EU 7th Framework Programme Grant 304936 and CÚRAM Science Foundation Ireland (SFI) Grant 13/RC/2073. A.P. was supported by Malaysia Ministry of Education. T.S. was supported by by Covidien LLC. A.P. and S.M. were supported by CÚRAM Science Foundation Ireland (SFI) Grant 13/RC/2073.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherAmerican Chemical Societyen_IE
dc.relation.ispartofACS Biomaterials Science & Engineeringen
dc.subjectspinal cord injuryen_IE
dc.subjecthemisectionen_IE
dc.subjecthydrogelen_IE
dc.subjectcollagenen_IE
dc.subjectmicrospheresen_IE
dc.subjectneurotrophin-3en_IE
dc.subjectNEURAL STEM-CELLSen_IE
dc.subjectAXONAL REGENERATIONen_IE
dc.subjectFUNCTIONAL RECOVERYen_IE
dc.subjectNERVOUS-SYSTEMen_IE
dc.subjectCORTICOSPINAL TRACTen_IE
dc.subjectGLIAL SCARen_IE
dc.subjectREPAIRen_IE
dc.subjectGENEen_IE
dc.subjectNT-3en_IE
dc.subjectDELIVERYen_IE
dc.titleTherapeutic effect of neurotrophin-3 treatment in an injectable collagen scaffold following rat spinal cord hemisection injuryen_IE
dc.typeArticleen_IE
dc.date.updated2019-07-25T11:55:55Z
dc.identifier.doi10.1021/acsbiomaterials.6b00167
dc.local.publishedsourcehttps://doi.org/10.1021/acsbiomaterials.6b00167en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderCovidien LLCen_IE
dc.contributor.funderIDA Irelanden_IE
dc.contributor.funderSeventh Framework Programmeen_IE
dc.contributor.funderScience Foundation Irelanden_IE
dc.internal.rssid12957736
dc.local.contactSiobhan Mcmahon, Department Of Anatomy, Nui, Galway. 2838 Email: siobhan.mcmahon@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/304936/EU/Development of Functionalised Cell Seeded Bioartificial Organ for Transplantation in Nerve Repair/NEUROGRAFTen_IE
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/en_IE
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