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Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord

Donnelly, Eleanor M.; Madigan, Nicolas N.; Rooney, Gemma E.; Knight, Andrew; Chen, Bingkun; Ball, Bret; Kinnavane, Lisa; Garcia, Yolanda; Dockery, Peter; Fraher, John; Strappe, Padraig M.; Windebank, Anthony J.; O'Brien, Timothy; McMahon, Siobhan S. (Elsevier, 2012-01-08)

Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ...