Browsing Anatomy (Scholarly Articles) by Author "McMahon, Siobhan S."
Now showing items 1-9 of 9
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Cell viability in three ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan S. (Wiley, 2018-11-11)Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ... -
Comparison of cellular architecture, axonal growth, and blood vessel formation through cell-loaded polymer scaffolds in the transected rat spinal cord
Madigan, Nicolas N.; Chen, Bingkun K.; Knight, Andrew M.; Rooney, Gemma E.; Sweeney, Eva; Kinnavane, Lisa; Yaszemski, Michael J.; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S.; Windebank, Anthony J. (Mary Ann Liebert, 2014-08-08)The use of multichannel polymer scaffolds in a complete spinal cord transection injury serves as a deconstructed model that allows for control of individual variables and direct observation of their effects on regeneration. ... -
Differential glycosylation expression in injured rat spinal cord treated with immunosuppressive drug Cyclosporin-A.
Kilcoyne, Michelle; Patil, Vaibhav; O'Grady, Claire; Bradley, Ciara; McMahon, Siobhan S. (American Chemical Society, 2019-02-12)Glycosylation is ubiquitous throughout the central nervous system and altered following spinal cord injury (SCI). The glial scar that forms following SCI is composed of several chondroitin sulfate proteoglycans, which ... -
Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ... -
Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Shaw, Georgina; Garcia, Yolanda; Sweeney, Eva; Hynes, Jacqueline; Dockery, Peter; O'Brien, Timothy; Windebank, Anthony J.; Allsopp, Timothy E.; Barry, Frank P. (Elsevier, 2012-12-20)Background aims. Spinal cord injury is a devastating injury that impacts drastically on the victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem (NS) cells have been harvested from ... -
GDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in rats
Chen, Bingkun K.; Madigan, Nicolas N.; Hakim, Jeffrey S.; Dadsetan, Mahrokh; McMahon, Siobhan S.; Yaszemski, Michael J.; Windebank, Anthony J. (Wiley, 2017-03-10)Positively-charged oligo[poly(ethylene glycol)fumarate] (OPF+) is a biodegradable hydrogel used for spinal cord injury repair. We compared scaffolds containing primary Schwann cells (SCs) to scaffolds delivering SCs ... -
Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord
Donnelly, Eleanor M.; Madigan, Nicolas N.; Rooney, Gemma E.; Knight, Andrew; Chen, Bingkun; Ball, Bret; Kinnavane, Lisa; Garcia, Yolanda; Dockery, Peter; Fraher, John; Strappe, Padraig M.; Windebank, Anthony J.; O'Brien, Timothy; McMahon, Siobhan S. (Elsevier, 2012-01-08)Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ... -
Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar
Donnelly, Eleanor M.; Strappe, Padraig M.; McGinley, Lisa M.; Madigan, Nicolas N.; Geurts, Elizabeth; Rooney, Gemma E.; Windebank, Anthony J.; Fraher, John; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S. (Wiley, 2010)Background Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. ... -
Therapeutic effect of neurotrophin-3 treatment in an injectable collagen scaffold following rat spinal cord hemisection injury
Breen, Bridget A.; Kraskiewicz, Honorata; Ronan, Rachel; Kshiragar, Aniket; Patar, Azim; Sargeant, Timothy; Pandit, Abhay; McMahon, Siobhan S. (American Chemical Society, 2016-08-01)Spinal cord injury (SCI) patients display varying quantities of spinal cord tissue damage with injuries that present as complete, incomplete or compressive. One theory proposed to repair the injured spinal cord and regain ...