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dc.contributor.authorPettenuzzo, Andrea
dc.contributor.authorPigot, Rebecca
dc.contributor.authorRonconi, Luca
dc.date.accessioned2019-07-18T14:33:51Z
dc.date.available2019-07-18T14:33:51Z
dc.date.issued2016-04-07
dc.identifier.citationA. Pettenuzzo, R. Pigot, L. Ronconi* (2015) 'Metal-based glycoconjugates and their potential in targeted anticancer chemotherapy' Metallodrugs, 1 :36-61.en_IE
dc.identifier.issn2300-3618
dc.identifier.urihttp://hdl.handle.net/10379/15273
dc.description.abstractGlucose is a key source of energy and an essential nutrient for cell growth. Rapidly dividing cancer cells are well-known to require more nutrients and energy than normal ones to sustain their higher proliferation rates, and glucose is no exception. Therefore, the biomolecules involved in the promotion/regulation of the glycolytic flux may be regarded as potential targets for tackling tumor progression. Among all, glucose transporters (GLUTs), devoted to the recognition and cellular internalization of glucose, are largely overexpressed in tumors, thus indicating glycolysis as the major anaerobic glucose metabolism. Accordingly, such increased demand of glucose by fast-proliferating cancer cells makes it very attractive to selectively target tumor sites. In particular, tailored glucose-like substrates can be conjugated to chemotherapeutics (including metal-containing anticancer agents) so as to attain the site-specific delivery of drugs into the affected tissues. Progress in the development of metal-based glycoconjugates are here summarized and discussed.en_IE
dc.description.sponsorshipFinancial support by the National University of Ireland Galway (College of Science Postgraduate Research Scholarship to AP and RP; Millennium Fund Minor Project 2013 to LR), and the COST Action CM1105 - Functional metal complexes that bind to biomolecules (Short Term Scientific Mission - STSM Grant to RP) is gratefully acknowledged.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherDe Gruyter Openen_IE
dc.relation.ispartofMetallodrugsen
dc.subjectglycoconjugatesen_IE
dc.subjecttumor metabolismen_IE
dc.subjectWarburg effecten_IE
dc.subjectglycolysisen_IE
dc.subjectglucose transportersen_IE
dc.subjectmetallodrugsen_IE
dc.subjectdrug designen_IE
dc.subjectmedicinal inorganic chemistryen_IE
dc.subjecttargeted anticancer chemotherapyen_IE
dc.titleMetal-based glycoconjugates and their potential in targeted anticancer chemotherapyen_IE
dc.typeArticleen_IE
dc.date.updated2019-07-04T13:31:21Z
dc.identifier.doi10.1515/medr-2015-0002
dc.local.publishedsourcehttps://dx.doi.org/10.1515/medr-2015-0002en_IE
dc.description.peer-reviewedPeer reviewed
dc.contributor.funderCollege of Science Postgraduate Research Scholarship, National University of Ireland Galwayen_IE
dc.internal.rssid16747376
dc.local.contactLuca Ronconi, National University Of Ireland G, School Of Chemistry, University Road, Galway. 2481 Email: luca.ronconi@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionPUBLISHED
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