Show simple item record

dc.contributor.authorMercer, Conan
dc.contributor.authorBennett, Richard
dc.contributor.authorÓ Conghaile, Peter
dc.contributor.authorRusling, James F.
dc.contributor.authorLeech, Dónal
dc.date.accessioned2019-06-24T08:33:36Z
dc.date.issued2019-02-17
dc.identifier.citationMercer, Conan, Bennett, Richard, Conghaile, Peter Ó, Rusling, James F., & Leech, Dónal. (2019). Glucose biosensor based on open-source wireless microfluidic potentiostat. Sensors and Actuators B: Chemical, 290, 616-624. doi: https://doi.org/10.1016/j.snb.2019.02.031en_IE
dc.identifier.issn0925-4005
dc.identifier.urihttp://hdl.handle.net/10379/15246
dc.description.abstractWireless potentiostats capable of cyclic voltammetry and amperometry that connect to the Internet are emerging as key attributes of future point-of-care devices. This work presents an "integrated microfluidic electrochemical detector" (iMED) three-electrode multi-potentiostat designed around operational amplifiers connected to a powerful WiFi-based microcontroller as a promising alternative to more expensive and complex strategies reported in the literature. The iMED is integrated with a microfluidic system developed to be controlled by the same microcontroller. The iMED is programmed wirelessly over a standard WiFi network and all electrochemical data is uploaded to an open-source cloud-based server. A wired desktop computer is not necessary for operation or program uploading. This method of integrated microfluidic automation is simple, uses common and inexpensive materials, and is compatible with commercial sample injectors. An integrated biosensor platform contains four screen-printed carbon arrays inside 4 separate microfluidic detection chambers with Pt counter and pseudo Ag/AgCl reference electrodes in situ. The iMED is benchmarked with K-3[Fe(CN)(6)] against a commercial potentiostat and then as a glucose biosensor using glucose-oxidising films of [Os(2,2'-bipyridine)(2)(polyvinylimidazole)(10)Cl] prepared on screen-printed electrodes with multi walled carbon nanotubes, poly(ethylene glycol) diglycidyl ether and flavin adenine dinucleotide-dependent glucose dehydrogenase. Potential application of this cost-effective wireless potentiostat approach to modern bioelectronics and point-of-care diagnosis is demonstrated by production of glucose oxidation currents, under pseudo-physiological conditions, using mediating films with lower redox potentials.en_IE
dc.description.sponsorshipThis work was supported financially by Science Foundation Ireland under the US/Ireland programme (Grant Number 13/US/B2546).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofSensors And Actuators B-Chemicalen
dc.subjectWirelessen_IE
dc.subjectOpen-sourceen_IE
dc.subjectEnzyme-based biosensoren_IE
dc.subjectMicrofluidic biosensoren_IE
dc.subjectSmartphoneen_IE
dc.subjectIoTen_IE
dc.subjectPOLYMER ENZYME ELECTRODESen_IE
dc.subjectLOW-COSTen_IE
dc.subjectREDOX POLYMERen_IE
dc.subjectMINIATURIZED POTENTIOSTATen_IE
dc.subjectCARBON NANOTUBESen_IE
dc.subjectBIOFUEL CELLen_IE
dc.subjectLABen_IE
dc.subjectPLATFORMen_IE
dc.subjectIMMUNOASSAYSen_IE
dc.subjectTRANSMISSIONen_IE
dc.titleGlucose biosensor based on open-source wireless microfluidic potentiostaten_IE
dc.typeArticleen_IE
dc.date.updated2019-06-21T17:04:27Z
dc.identifier.doi10.1016/j.snb.2019.02.031
dc.local.publishedsourcehttps://doi.org/10.1016/j.snb.2019.02.031en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.description.embargo2021-02-17
dc.internal.rssid16268988
dc.local.contactDonal Leech, School Of Chemistry, Room C228 Arts/Science Building, University Road, Nui Galway. 5349 Email: donal.leech@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionSUBMITTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI US Ireland R&D Partnership/13/US/B2546/IE/Protein Biomarker Arrays for Personalized Treatment of Prostate Cancer/en_IE
nui.item.downloads0


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record