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dc.contributor.authorJones, Marggie
dc.contributor.authorMcDermott, Barry
dc.contributor.authorOliveira, Bárbara Luz
dc.contributor.authorO'Brien, Aoife
dc.contributor.authorCoogan, Declan
dc.contributor.authorLang, Mark
dc.contributor.authorMoriarty, Niamh
dc.contributor.authorDowd, Eilis
dc.contributor.authorQuinlan, Leo
dc.contributor.authorMc Ginley, Brian
dc.contributor.authorDunne, Eoghan
dc.contributor.authorNewell, David
dc.contributor.authorPorter, Emily
dc.contributor.authorElahi, Muhammad Adnan
dc.contributor.authorO' Halloran, Martin
dc.contributor.authorShahzad, Atif
dc.identifier.citationJones, Marggie, McDermott, Barry, Oliveira, Bárbara Luz, O'Brien, Aoife, Coogan, Declan, Lang, Mark, Moriarty, Niamh Dowd, Eilis,Quinlan, Leo, Mc Ginley, Brian, Dunne, Eoghan, Newell, David,Porter, Emily, Elahi, Muhammad Adnan O' Halloran, Martin, Shahzad, Atif. (2019). Gamma band light stimulation in human case studies: Groundwork for potential Alzheimer's disease treatment. Journal of Alzheimer's Disease, 1-15. doi: 10.3233/JAD-190299en_IE
dc.description.abstractIt is known that proteins associated with Alzheimer's disease (AD) pathogenesis are significantly reduced by 40¿Hz entrainment in mice. If this were to translate to humans, verifying that such a light stimulus can induce a 40¿Hz entrainment response in humans and harnessing insights from these case studies could be one step in the development of a multisensory device to prevent and treat AD. Verify the inducement of a 40¿Hz response in the human brain by a 40¿Hz light stimulus and obtain insights that could potentially aid in the development of a multisensory device for the prevention and treatment of AD. Electroencephalographic brain activity was recorded simultaneously with application of stimulus at different frequencies and intensities. Power spectral densities were analyzed. Entrainment to visual stimuli occurred with the largest response at 40¿Hz. The high intensity 40¿Hz stimulus caused widespread entrainment. The number of electrodes demonstrating entrainment increased with increasing light intensity. Largest amplitudes for the high intensity 40¿Hz stimulus were consistently found at the primary visual cortex. There was a harmonic effect at double the frequency for the 40¿Hz stimulus. An eyes-open protocol caused more entrainment than an eyes-closed protocol. It was possible to induce widespread entrainment using a 40¿Hz light stimulus in this sample cohort. Insights gleaned from these case studies could potentially aid in the development of a multisensory medical device to prevent and treat AD.en_IE
dc.publisherIOS Pressen_IE
dc.relation.ispartofJournal Of Alzheimers Diseaseen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subject40 Hzen_IE
dc.subjectAlzheimer’s diseaseen_IE
dc.subjectgamma banden_IE
dc.subjecthuman studyen_IE
dc.subjectlight stimulusen_IE
dc.titleGamma band light stimulation in human case studies: Groundwork for potential Alzheimer's disease treatmenten_IE
dc.local.contactBarry Mc Dermott, Translational Medical Device Lab, , 2nd Floor Lambe Translational Research Facility,, University College Hospital, , Galway. - Email:

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