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Conversion of gel-forming crystal needles to easily processable more equant crystals Using high-shear ultralow attrition agitation: accelerated Ostwald ripening without crystal attrition

dc.contributor.authorCivati, Francesco
dc.contributor.authorErxleben, Andrea
dc.contributor.authorKellehan, Seamus
dc.contributor.authorMcArdle, Patrick
dc.date.accessioned2019-06-05T12:24:59Z
dc.date.issued2019-02-01
dc.identifier.citationCivati, Francesco, Erxleben, Andrea, Kellehan, Seamus, & McArdle, Patrick. (2019). Conversion of Gel-Forming Crystal Needles To Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition. Crystal Growth & Design, 19(3), 1502-1504. doi: 10.1021/acs.cgd.8b01650en_IE
dc.identifier.issn1528-7505
dc.identifier.urihttp://hdl.handle.net/10379/15211
dc.description.abstractWe demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution shearing to accelerate mass transfer, diflunisal and isonicotinohydrazide gels are transformed into easily filterable crystals. High-shear ultralow attrition agitation conditions are generated by spinning with rapid reversal of the spinning direction every three seconds.en_IE
dc.description.sponsorshipThis publication has emanated from research supported in part by a research grant from Science Foundation Ireland (SFI) and is cofunded under the European Regional Development Fund under Grant Number 12/RC/2275.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherAmerican Chemical Societyen_IE
dc.relation.ispartofCrystal Growth & Designen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectMORPHOLOGYen_IE
dc.subjectDISSOLUTIONen_IE
dc.subjectPROGRAMen_IE
dc.subjectGROWTHen_IE
dc.titleConversion of gel-forming crystal needles to easily processable more equant crystals Using high-shear ultralow attrition agitation: accelerated Ostwald ripening without crystal attritionen_IE
dc.typeArticleen_IE
dc.date.updated2019-05-30T11:45:31Z
dc.identifier.doi10.1021/acs.cgd.8b01650
dc.local.publishedsourcehttps://doi.org/10.1021/acs.cgd.8b01650en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.description.embargo2020-02-01
dc.internal.rssid16091864
dc.local.contactAndrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en_IE
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland