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dc.contributor.authorDolan, Eimear B.
dc.contributor.authorHofmann, Björn
dc.contributor.authorde Vaal, M. Hamman
dc.contributor.authorBellavia, Gabriella
dc.contributor.authorStraino, Stefania
dc.contributor.authorKovarova, Lenka
dc.contributor.authorPravda, Martin
dc.contributor.authorVelebny, Vladimir
dc.contributor.authorDaro, Dorothee
dc.contributor.authorBraun, Nathalie
dc.contributor.authorMonahan, David S.
dc.contributor.authorLevey, Ruth E.
dc.contributor.authorO'Neill, Hugh
dc.contributor.authorHinderer, Svenja
dc.contributor.authorGreensmith, Robert
dc.contributor.authorMonaghan, Michael G.
dc.contributor.authorSchenke-Layland, Katja
dc.contributor.authorDockery, Peter
dc.contributor.authorMurphy, Bruce P.
dc.contributor.authorKelly, Helena M.
dc.contributor.authorWildhirt, Stephen
dc.contributor.authorDuffy, Garry P.
dc.date.accessioned2019-05-22T13:16:12Z
dc.date.issued2019-05-15
dc.identifier.citationDolan, Eimear B., Hofmann, Björn, de Vaal, M. Hamman, Bellavia, Gabriella, Straino, Stefania, Kovarova, Lenka, Pravda, Martin, Velebny, Vladimir, Daro, Dorothee, Braun, Nathalie, Monahan, David S., Levey, Ruth E., O'Neill, Hugh, Hinderer, Svenja, Greensmith, Robert, Monaghan, Michael G., Schenke-Layland, Katja, Dockery, Peter, Murphy, Bruce P., Kelly,, Helena M., Wildhirt, Stephen, Duffy, Garry P. (2019). A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction. Materials Science and Engineering: C, 103, 109751. doi: https://doi.org/10.1016/j.msec.2019.109751en_IE
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/10379/15192
dc.description.abstractThe limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the weakened myocardium and regenerative approaches (specifically stem cell technologies) have evolved which aim to prevent CHF. However, their final performance remains limited motivating the need for an advanced strategy with enhanced efficacy and reduced deleterious effects. An epicardial carrier device enabling a targeted application of a biomaterial-based therapy to the infarcted ventricle wall could potentially overcome the therapy and application related issues. Such a device could play a synergistic role in heart regeneration, including the provision of mechanical support to the remodeling heart wall, as well as providing a suitable environment for in situ stem cell delivery potentially promoting heart regeneration. In this study, we have developed a novel, single-stage concept to support the weakened myocardial region post-MI by applying an elastic, biodegradable patch (SPREADS) via a minimal-invasive, closed chest intervention to the epicardial heart surface. We show a significant increase in %LVEF 14 days post-treatment when GS (clinical gold standard treatment) was compared to GS + SPREADS + Gel with and without cells (p ≤ 0.001). Furthermore, we did not find a significant difference in infarct quality or blood vessel density between any of the groups which suggests that neither infarct quality nor vascularization is the mechanism of action of SPREADS. The SPREADS device could potentially be used to deliver a range of new or previously developed biomaterial hydrogels, a remarkable potential to overcome the translational hurdles associated with hydrogel delivery to the heart.en_IE
dc.description.sponsorshipAMCARE project funded by European Union's ‘Seventh Framework’ Programme for research, technological development and demonstration under Grant Agreement n° NMP3-SME-2013-604531. David Monahan is funded by the Irish Research Council Government of Ireland Postgraduate Scholarship (GOIPG/2017/927) and the College of Medicine, Nursing and Health Sciences at the National University of Ireland Galway. Scott Robinson for statistical analysis. The authors acknowledge the facilities, scientific, and technical assistance of the Centre for Microscopy & Imaging at the National University of Ireland Galway.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofMaterials Science And Engineeringen
dc.subjectVentricular stabilizationen_IE
dc.subjectEpicardial carrier deviceen_IE
dc.subjectExtravascular deviceen_IE
dc.subjectHyaluronic acid hydrogelen_IE
dc.subjectStem cell deliveryen_IE
dc.subjectMyocardial infarctionen_IE
dc.titleA bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarctionen_IE
dc.typeArticleen_IE
dc.date.updated2019-05-22T11:35:19Z
dc.identifier.doi10.1016/j.msec.2019.109751
dc.local.publishedsourcehttps://doi.org/10.1016/j.msec.2019.109751en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderSeventh Framework Programmeen_IE
dc.contributor.funderIrish Research Councilen_IE
dc.contributor.funderCollege of Medicine, Nursing and Health Sciences, National University of Ireland Galwayen_IE
dc.description.embargo2021-05-15
dc.internal.rssid16255561
dc.local.contactEimear Dolan, Biomedical Engineering 3031, College Of Engineering & Informa, Nui Galway. Email: eimear.dolan@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::NMP/604531/EU/Advanced Materials for Cardiac Regeneration (AMCARE)/AMCAREen_IE
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