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dc.contributor.authorMoriarty, Orla
dc.contributor.authorLang, Yvonne
dc.contributor.authorIdrees, Zubair
dc.contributor.authorMcGuire, Brian E.
dc.contributor.authorFinn, David P.
dc.date.accessioned2019-04-02T13:37:37Z
dc.date.available2019-04-02T13:37:37Z
dc.date.issued2016-01-13
dc.identifier.citationMoriarty, Orla, Lang, Yvonne, Idrees, Zubair, McGuire, Brian E., & Finn, David P. (2016). Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy. Behavioural Brain Research, 303, 61-70., doi: 10.1016/j.bbr.2016.01.027en_IE
dc.identifier.issn1872-7549
dc.identifier.urihttp://hdl.handle.net/10379/15088
dc.description.abstractDiabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and cognitive function in the rat streptozotocin (STZ) model of diabetes, and assessed cannabinoid(1) (CB1) receptor functionality in discrete brain regions. Male Lister-Hooded rats received STZ (60 mg/kg s.c.) or vehicle. Sensory responses were assessed in von Frey and Hargreaves tests. Cognitive, motor and sensorimotor functions were assessed using novel object recognition and Morris water maze tasks. CB1 receptor functionality was assessed by [S-35]GTP gamma S (guanosine 5'-O-[gamma-thio]triphosphate) autoradiography. STZ treatment was associated with mechanical allodynia and thermal hypoalgesia. Novel object recognition was unaltered in diabetic rats. STZ treatment was associated with impaired performance in the Morris water maze acquisition phase, but there were no differences in memory retrieval in the probe trial. Stimulus-response learning in the water maze cued trial was also disrupted in STZ-treated rats, possibly indicating sensorimotor deficits. CB1 receptor agonist-stimulated [S-35]GTP gamma S binding was attenuated in the substantia nigra of STZ-treated rats but unaltered in the hippocampus. In conclusion, STZ treatment as a model of diabetic neuropathy was associated with specific functional deficits in the Morris water maze, effects which may be related to altered CB1 receptor functionality in the substantia nigra. (C) 2016 Elsevier B.V. All rights reserved.en_IE
dc.description.sponsorshipThis work was supported financially by grants from Science Foundation Ireland (05/Y12/B686) and by the Irish Higher Education Authority's Programme for Research in Third Level Institutions Cycle 4 (National Development Plan 2007–2013) through the National Biophotonics and Imaging Platform.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofBehavioural Brain Researchen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectDiabetesen_IE
dc.subjectStreptozotocinen_IE
dc.subjectNeuropathic painen_IE
dc.subjectMorris water mazeen_IE
dc.subjectCannabinoid(1) (CB1) receptoren_IE
dc.subject[S-35]GTP gamma S bindingen_IE
dc.subjectHIPPOCAMPAL SYNAPTIC PLASTICITYen_IE
dc.subjectCOGNITIVE DYSFUNCTIONen_IE
dc.subjectTACTILE ALLODYNIAen_IE
dc.subjectDOPAMINE NEURONSen_IE
dc.subjectMEMORY DEFICITSen_IE
dc.subjectPARS COMPACTAen_IE
dc.subjectCHRONIC PAINen_IE
dc.subjectWATER MAZEen_IE
dc.subjectBRAINen_IE
dc.subjectMELLITUSen_IE
dc.titleImpaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathyen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-28T05:30:10Z
dc.identifier.doi10.1016/j.bbr.2016.01.027
dc.local.publishedsourcehttps://doi.org/10.1016/j.bbr.2016.01.027en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderHigher Education Authorityen_IE
dc.contributor.funderNational Biophotonics and Imaging Platform, Irelanden_IE
dc.internal.rssid10893609
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Short Term Travel Fellowship (STTF)/05/Y12/B686 STTF 08/IE/Control of endogenous analgesia by the brain endocannabinoid system: sites and mechanisms of action/en_IE
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