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dc.contributor.authorJennings, Elaine M.
dc.contributor.authorOkine, Bright N.
dc.contributor.authorOlango, Weredeselam M.
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2019-04-01T10:40:57Z
dc.date.available2019-04-01T10:40:57Z
dc.date.issued2015-05-16
dc.identifier.citationJennings, Elaine M., Okine, Bright N., Olango, Weredeselam M., Roche, Michelle, & Finn, David P. (2016). Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 64, 181-189. doi: https://doi.org/10.1016/j.pnpbp.2015.05.008en_IE
dc.identifier.issn1878-4216
dc.identifier.urihttp://hdl.handle.net/10379/15084
dc.description.abstractRepeated exposure to a homotypic stressor such as forced swimming enhances nociceptive responding in rats. However, the influence of genetic background on this stress-induced hyperalgesia is poorly understood. The aim of the present study was to compare the effects of repeated forced swim stress on nociceptive responding in Sprague-Dawley (SD) rats versus the Wistar Kyoto (WKY) rat strain, a genetic background that is susceptible to stress, negative affect and hyperalgesia. Given the well-documented role of the endocannabinoid system in stress and pain, we investigated associated alterations in endocannabinoid signalling in the dorsal horn of the spinal cord and amygdala. In SD rats, repeated forced swim stress for 10 days was associated with enhanced late phase formalin-evoked nociceptive behaviour, compared with naive, non-stressed SD controls. In contrast, WKY rats exposed to 10 days of swim stress displayed reduced late phase formalin-evoked nociceptive behaviour. Swim stress increased levels of monoacylglycerol lipase (MAGL) mRNA in the ipsilateral side of the dorsal spinal cord of SD rats, an effect not observed in WKY rats. In the amygdala, swim stress reduced anandamide (AEA) levels in the contralateral amygdala of SD rats, but not WKY rats. Additional within-strain differences in levels of CB1 receptor and fatty acid amide hydrolase (FAAH) mRNA and levels of 2-arachidonylglycerol (2-AG) were observed between the ipsilateral and contralateral sides of the dorsal horn and/or amygdala. These data indicate that the effects of repeated stress on inflammatory pain-related behaviour are different in two rat strains that differ with respect to stress responsivity and affective state and implicate the endocannabinoid system in the spinal cord and amygdala in these differences. (C) 2015 Elsevier Inc. All rights reserved.en_IE
dc.description.sponsorshipThis work was funded by grants from Science Foundation Ireland (10/IN.1/B2976) and the Irish Research Council. These funding agencies played no part in study design; in the collection, analysis of and interpretation data; in the writing of the report; or in the decision to submit the article for publication.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatryen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectEndocannabinoiden_IE
dc.subjectPainen_IE
dc.subjectSprague-Dawleyen_IE
dc.subjectStress-induced hyperalgesiaen_IE
dc.subjectWistar Kyotoen_IE
dc.subjectFEAR-CONDITIONED ANALGESIAen_IE
dc.subjectACID AMIDE HYDROLASEen_IE
dc.subjectEARLY-LIFE STRESSen_IE
dc.subjectCANNABINOID RECEPTORen_IE
dc.subjectBASOLATERAL AMYGDALAen_IE
dc.subjectINDUCED HYPERALGESIAen_IE
dc.subjectMOLECULAR CHARACTERIZATIONen_IE
dc.subjectPAIN MODULATIONen_IE
dc.subjectCB1 RECEPTORSen_IE
dc.subjectADULT-RATen_IE
dc.titleRepeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strainsen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-28T05:09:30Z
dc.identifier.doi10.1016/j.pnpbp.2015.05.008
dc.local.publishedsourcehttps://doi.org/10.1016/j.pnpbp.2015.05.008en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderIrish Research Councilen_IE
dc.internal.rssid9874170
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/10/IN.1/B2976/IE/The role of the endocannabinoid system in anxiety-induced modulation of pain: sites and mechanisms of action/en_IE
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