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dc.contributor.authorMoriarty, Niamh
dc.contributor.authorPandit, Abhay
dc.contributor.authorDowd, Eilís
dc.date.accessioned2019-03-20T13:47:38Z
dc.date.available2019-03-20T13:47:38Z
dc.date.issued2017-11-22
dc.identifier.citationMoriarty, Niamh, Pandit, Abhay, & Dowd, Eilís. (2017). Encapsulation of primary dopaminergic neurons in a GDNF-loaded collagen hydrogel increases their survival, re-innervation and function after intra-striatal transplantation. Scientific Reports, 7(1), 16033. doi: 10.1038/s41598-017-15970-wen_IE
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10379/15032
dc.description.abstractPoor graft survival limits the use of primary dopaminergic neurons for neural repair in Parkinson's disease. Injectable hydrogels have the potential to significantly improve the outcome of such reparative approaches by providing a physical matrix for cell encapsulation which can be further enriched with pro-survival factors. Therefore, this study sought to determine the survival and efficacy of primary dopaminergic grafts after intra-striatal delivery in a glial-derived neurotrophic factor (GDNF)-loaded collagen hydrogel in a rat model of Parkinson's disease. After intra-striatal transplantation into the lesioned striatum, the GDNF-enriched collagen hydrogel significantly improved the survival of dopaminergic neurons in the graft (5-fold), increased their capacity for striatal re-innervation (3-fold), and enhanced their functional efficacy. Additional studies suggested that this was due to the hydrogel's ability to retain GDNF in the microenvironment of the graft, and to protect the transplanted cells from the host immune response. In conclusion, the encapsulation of dopaminergic neurons in a GDNF-loaded hydrogel dramatically increased their survival and function, providing further evidence of the potential of biomaterials for neural transplantation and brain repair in neurodegenerative diseases such as Parkinson's disease.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherNature Researchen_IE
dc.relation.ispartofScientific Reportsen
dc.subjectCELL-SUSPENSION GRAFTSen_IE
dc.subjectPARKINSONS-DISEASEen_IE
dc.subjectRAT-BRAINen_IE
dc.subjectNEUROTROPHIC FACTORen_IE
dc.subjectTIME-COURSEen_IE
dc.subjectSTEM-CELLSen_IE
dc.subjectBIOMATERIALSen_IE
dc.subjectDELIVERYen_IE
dc.subjectTISSUEen_IE
dc.subjectMESENCEPHALONen_IE
dc.titleEncapsulation of primary dopaminergic neurons in a GDNF-loaded collagen hydrogel increases their survival, re-innervation and function after intra-striatal transplantationen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-15T15:06:49Z
dc.identifier.doi10.1038/s41598-017-15970-w
dc.local.publishedsourcehttps://dx.doi.org/10.1038/s41598-017-15970-wen_IE
dc.description.peer-reviewedpeer-reviewed
dc.internal.rssid13566750
dc.local.contactEilís Dowd, Dept Of Pharmacology, Nui, Galway.. 2776 Email: eilis.dowd@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionPUBLISHED
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