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dc.contributor.authorKrukiewicz, Katarzyna
dc.contributor.authorJanas, Dawid
dc.contributor.authorVallejo-Giraldo, Catalina
dc.contributor.authorBiggs, Manus J. P.
dc.date.accessioned2019-03-15T08:25:34Z
dc.date.issued2018-10-26
dc.identifier.citationKrukiewicz, Katarzyna, Janas, Dawid, Vallejo-Giraldo, Catalina, & Biggs, Manus J. P. (2019). Self-supporting carbon nanotube films as flexible neural interfaces. Electrochimica Acta, 295, 253-261. doi: https://doi.org/10.1016/j.electacta.2018.10.157en_IE
dc.identifier.issn0013-4686
dc.identifier.urihttp://hdl.handle.net/10379/15024
dc.description.abstractAdvances in neural interface technologies have sought to identify electroactive materials that are able to translate neural depolarisation events into digital signals or modulate neural firing through ionic or electrical stimulation with greater efficiency. An ideal material for neural recording and/or stimulation should possess low electrical impedance coupled with a high cathodic charge storage capacity (CSCC), charge injection capacity (CIC) and electroactive surface area (ESA), as well as optimal mechanical biomimicry. In this study, we present the robustness of self-supporting CNT films as neural interfaces, combining advantageous electrical and mechanical properties with high cytocompatibility. Films were observed to possess a high CSCC (29.95 +/- 0.91 mC cm(-2)), CIC (352 +/- 5 mu CV-1 cm(-2)) and ESA (0.908 +/- 0.053 cm(2)), low impedance (110 Omega at 1 kHz), low resistance (75 +/- 13 Omega) and high capacitance (378 +/- 9 mu F cm(-2)), and outperformed Pt control electrodes. Self-supporting CNT films were also found to facilitate neuron growth and decrease the presence of reactive astrocytes in a mixed neural cell population. Self-standing CNT films were shown to be promising materials for the design of flexible and cytocompatible neural interfaces. (C) 2018 Elsevier Ltd. All rights reserved.en_IE
dc.description.sponsorshipThis publication has emanated from research conducted with the financial support of Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073 and SFI Technology Innovation Development Programme, grant no. 15/TIDA/2992. This project has received funding from National Science Center, Poland (under the Polonez program, grant agreement UMO-2015/19/P/ST5/03799) and the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreements No. 713690 and 665778. The authors acknowledge the facilities and scientific and technical assistance of the Center for Microscopy & Imaging at the National University of Ireland Galway, a facility that is funded by NUIG and the Irish Government's Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007–2013. D.J. and K.K. would also like to acknowledge the Ministry for Science and Higher Education for the scholarship for outstanding young scientists (0388/E-367/STYP/12/2017 and 649/STYP/12/2017, respectively).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofElectrochimica Actaen
dc.subjectDEEP BRAIN-STIMULATIONen_IE
dc.subjectCHARGE-INJECTION-CAPACITYen_IE
dc.subjectELECTRICAL-STIMULATIONen_IE
dc.subjectMICROELECTRODE ARRAYSen_IE
dc.subjectPARKINSONS-DISEASEen_IE
dc.subjectELECTRODESen_IE
dc.subjectFREQUENCYen_IE
dc.subjectCOMPOSITEen_IE
dc.subjectIMPEDANCEen_IE
dc.subjectTISSUEen_IE
dc.titleSelf-supporting carbon nanotube films as flexible neural interfacesen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-12T12:59:47Z
dc.identifier.doi10.1016/j.electacta.2018.10.157
dc.local.publishedsourcehttps://doi.org/10.1016/j.electacta.2018.10.157en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.contributor.funderNational Science Center, Polanden_IE
dc.contributor.funderHorizon 2020en_IE
dc.description.embargo2020-10-26
dc.internal.rssid16006712
dc.local.contactManus Biggs, Nfb, Nui Galway. Email: manus.biggs@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2992/IE/Biomimetic electrically conducting polymer scaffolds as novel neuromodulatory neuroelectrodes for the treatment of chronic pain/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative./MedTrainen_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/665778/EU/SUPPORTING MOBILITY IN THE ERA THROUGH AN INTERNATIONAL FELLOWSHIP PROGRAMME FOR DEVELOPEMENT OF BASIC RESEARCH IN POLAND/POLONEZen_IE
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