dc.contributor.author | Krukiewicz, Katarzyna | |
dc.contributor.author | Chudy, Magdalena | |
dc.contributor.author | Vallejo-Giraldo, Catalina | |
dc.contributor.author | Skorupa, Małgorzata | |
dc.contributor.author | Więcławska, Daria | |
dc.contributor.author | Turczyn, Roman | |
dc.contributor.author | Biggs, Manus | |
dc.date.accessioned | 2019-03-14T13:03:44Z | |
dc.date.issued | 2018-06-04 | |
dc.identifier.citation | Krukiewicz, Katarzyna, Chudy, Magdalena, Vallejo-Giraldo, Catalina, Skorupa, Małgorzata, Więcławska, Daria, Turczyn, Roman, & Biggs, Manus. (2018). Fractal form PEDOT/Au assemblies as thin-film neural interface materials. Biomedical Materials, 13(5), 054102. doi: 10.1088/1748-605x/aabced | en_IE |
dc.identifier.issn | 1748-605X | |
dc.identifier.uri | http://hdl.handle.net/10379/15021 | |
dc.description.abstract | Electrically conducting polymer formulations have emerged as promising approaches for the development of interfaces and scaffolds in neural engineering, facilitating the development of physicochemically modified constructs capable of cell stimulation through electrical and ionic charge transfer. In particular, topographically functionalized or neuromorphic materials are able to guide the growth of axons and promote enhanced interfacing with neuroelectrodes in vitro. In this study, we present a novel method for the formation of conducting polymer/gold assemblies via a combinational sputter and spin coating technique. The resulting multilayered PEDOT/Au substrates possessed enhanced electrochemical properties as a function of the number of deposited organic/inorganic layers. It was observed that through subsequent electrochemical conditioning it was possible to form neuromorphic fractal-like assemblies of gold particles, which significantly impacted on the electrochemical characteristics of the PEDOT/Au films. PEDOT/Au assemblies were observed to possess unique topographical features, advantageous charge storage capacity (34.9 ± 2.6 mC cm−2) and low electrical impedance (30 ± 2 Ω at 1 kHz). Furthermore, PEDOT/Au assemblies were observed to facilitate the outgrowth of neurites in a mixed ventral mesencephalon cell population and promotean increase in the neurons/astrocytes ratio relative to all experimental groups, indicating PEDOT/Au biomimetic neuromorphic assemblies as promising materials in engineering electrically conductive neural interface systems. | en_IE |
dc.description.sponsorship | This publication has emanated from research conducted with the financial support of Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 713690 and SFI Technology Innovation Development Programme, grant no. 15/TIDA/2992. The authors acknowledge the facilities and scientific and technical assistance of the Center for Microscopy & Imaging at the National University of Ireland Galway, a facility that is funded by NUIG and the Irish Government's Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007–2013. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | IOP Publishing | en_IE |
dc.relation.ispartof | Biomedical Materials | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | PEDOT/Au assemblies | en_IE |
dc.subject | Thin-film | en_IE |
dc.subject | Neural interface | en_IE |
dc.subject | Fractal form | en_IE |
dc.title | Fractal form PEDOT/Au assemblies as thin-film neural interface materials | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2019-03-12T12:56:41Z | |
dc.identifier.doi | 10.1088/1748-605x/aabced | |
dc.local.publishedsource | https://doi.org/10.1088/1748-605X/aabced | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | Science Foundation Ireland | en_IE |
dc.contributor.funder | European Regional Development Fund | en_IE |
dc.contributor.funder | Horizon 2020 | en_IE |
dc.description.embargo | 2019-06-04 | |
dc.internal.rssid | 16006707 | |
dc.local.contact | Manus Biggs, Nfb, Nui Galway. Email: manus.biggs@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
dcterms.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/ | en_IE |
dcterms.project | info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative./MedTrain | en_IE |
dcterms.project | info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2992/IE/Biomimetic electrically conducting polymer scaffolds as novel neuromodulatory neuroelectrodes for the treatment of chronic pain/ | en_IE |
nui.item.downloads | 288 | |