Show simple item record

dc.contributor.authorKrukiewicz, Katarzyna
dc.contributor.authorKowalik, Agnieszka
dc.contributor.authorCzerwinska-Glowka, Dominika
dc.contributor.authorBiggs, Manus J. P.
dc.date.accessioned2019-03-14T12:23:32Z
dc.date.issued2019-02-06
dc.identifier.citationKrukiewicz, Katarzyna, Kowalik, Agnieszka, Czerwinska-Glowka, Dominika, & Biggs, Manus J. P. (2019). Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: Cytocompatibility and electrochemical studies. Electrochimica Acta, 302, 21-30. doi:10.1016/j.electacta.2019.02.023en_IE
dc.identifier.issn0013-4686
dc.identifier.urihttp://hdl.handle.net/10379/15019
dc.description.abstractConducting polymers have been extensively reported as promising coating materials for applications involving interactions with electrically excitable tissues. Specifically, metal electrodes functionalized with conducting polymer coatings have been employed as biointerfaces presenting tailored properties to promote electrode integration as well as chronic functionality. Currently, polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT) represent the most extensively studied conducting polymers, exhibiting favourable electrochemical properties and biocompatibility. In this paper, we study electrodeposited poly(3,4-ethylenedioxypyrrole) (PEDOP), a conducting polymer which is structurally related to both PEDOT and PPy, and is expected to outperform its “parent” polymers in terms of electrochemical properties and biocompatibility. The performance of PEDOP doped with chloride/phosphate, p-toluenesulfonate or polystyrene sulfonate was subsequently investigated to assess the efficacy of these ionic dopants in promoting electrochemical stability and neural cytocompatibility. Electrodeposited PEDOP films exhibited a high charge storage capacity (50.07 ± 6.96 mC cm−2), charge injection capacity (203 ± 24 μC cm−2) and substantial stability (performance loss of 0.49 ± 0.06% after 100 000 stimulation pulses). Furthermore, PEDOP films promoted enhanced neuron outgrowth and viability relative to control substrates. In particular, PEDOP/PTS was shown to increase the average neurite length by a factor of three when compared with cells cultured on bare Pt control substrates. Consequently, due to its favourable electrochemical characteristics together with high neural cytocompatibility, PEDOP can be indicated as a promising alternative to PPy and PEDOT in the field of neural science.en_IE
dc.description.sponsorshipThis publication has emanated from research conducted with the financial support of Science Foundation Ireland and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713690 and SFI Technology Innovation Development Programme, grant no. 15/TIDA/2992. This work has been supported by the Polish National Science Centre in the framework of Sonata 2016/23/D/ST5/01306. The authors acknowledge the facilities and scientific and technical assistance of the Centre for Microscopy & Imaging at the National University of Ireland Galway, a facility that is funded by NUIG and the Irish Government's Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007–2013.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofElectrochimica Actaen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectConducting polymersen_IE
dc.subjectCytocompatibilityen_IE
dc.subjectNeural interfaceen_IE
dc.subjectPoly(3,4-ethylenedioxypyrrole)en_IE
dc.titleElectrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: Cytocompatibility and electrochemical studiesen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-12T11:23:57Z
dc.identifier.doi10.1016/j.electacta.2019.02.023
dc.local.publishedsourcehttps://doi.org/10.1016/j.electacta.2019.02.023en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.contributor.funderHorizon 2020en_IE
dc.contributor.funderPolish National Science Centreen_IE
dc.description.embargo2021-02-06
dc.internal.rssid16006668
dc.local.contactManus Biggs, Nfb, Nui Galway. Email: manus.biggs@nuigalway.ie
dc.local.copyrightcheckedYes
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative./MedTrainen_IE
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2992/IE/Biomimetic electrically conducting polymer scaffolds as novel neuromodulatory neuroelectrodes for the treatment of chronic pain/en_IE
nui.item.downloads145


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland