Computerised working memory‐based cognitive remediation therapy does not affect Reading the Mind in The Eyes test performance or neural activity during a Facial Emotion Recognition test in psychosis
Fagan, Andrew J.
Meaney, James F.
Robertson, Ian H.
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Mothersill, David, Dillon, Rachael, Hargreaves, April, Castorina, Marco, Furey, Emilia, Fagan, Andrew J., Meaney, James F., Fitzmaurice, Brian, Hallahan, Brian, McDonald, Colm, Wykes, Til, Corvin, Aiden, Robertson, Ian H., Donohoe, Gary. (2018). Computerised working memory-based cognitive remediation therapy does not affect Reading the Mind in The Eyes test performance or neural activity during a Facial Emotion Recognition test in psychosis. European Journal of Neuroscience, 48(1), 1691-1705. doi: doi:10.1111/ejn.13976
Working memory-based cognitive remediation therapy (CT) for psychosis has recently been associated with broad improvements in performance on untrained tasks measuring working memory, episodic memory and IQ, and changes in associated brain regions. However, it is unclear whether these improvements transfer to the domain of social cognition and neural activity related to performance on social cognitive tasks. We examined performance on the Reading the Mind in the Eyes test (Eyes test) in a large sample of participants with psychosis who underwent working memory-based CT (N=43) compared to a control group of participants with psychosis (N=35). In a subset of this sample, we used functional magnetic resonance imaging (fMRI) to examine changes in neural activity during a facial emotion recognition task in participants who underwent CT (N=15) compared to a control group (N=15). No significant effects of CT were observed on Eyes test performance or on neural activity during facial emotion recognition, either at p
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