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dc.contributor.authorCinelli, Ilaria
dc.contributor.authorDestrade, Michel
dc.contributor.authorDuffy, Maeve
dc.contributor.authorMcHugh, Peter
dc.date.accessioned2018-12-12T11:57:20Z
dc.date.available2018-12-12T11:57:20Z
dc.date.issued2017-11-21
dc.identifier.citationCinelli, I., Destrade, M., Duffy, M., & McHugh, P. (2018). Electro-mechanical response of a 3D nerve bundle model to mechanical loads leading to axonal injury. International Journal for Numerical Methods in Biomedical Engineering, 34(3), e2942, doi:10.1002/cnm.2942en_IE
dc.identifier.issn2040-7947
dc.identifier.urihttp://hdl.handle.net/10379/14691
dc.description.abstractTraumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the cellular level. The coupling is based on a thermal analogy of the neural electrical activity by using the finite element software Abaqus CAE 6.13-3. The model includes a real-time coupling, modulated threshold for spiking activation, and independent alteration of the electrical properties for each 3-layer fibre within a nerve bundle as a function of strain. Results of the coupled electro-mechanical model are validated with previously published experimental results of damaged axons. Here, the cases of compression and tension are simulated to induce (mild, moderate, and severe) damage at the nerve membrane of a nerve bundle, made of 4 fibres. Changes in strain, stress distribution, and neural activity are investigated for myelinated and unmyelinated nerve fibres, by considering the cases of an intact and of a traumatised nerve membrane. A fully coupled electro-mechanical modelling approach is established to provide insights into crucial aspects of neural activity at the cellular level due to traumatic brain injury. One of the key findings is the 3D distribution of residual stresses and strains at the membrane of each fibre due to mechanically induced electrophysiological impairments, and its impact on signal transmission.en_IE
dc.description.sponsorshipThe authors gratefully acknowledge funding from the Galway University Foundation, the Biomechanics Research Centre, and the Power Electronics Research Centre, College of Engineering and Informatics, National University of Ireland Galway (NUIG) in Galway, Rep. of Ireland.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherWileyen_IE
dc.relation.ispartofInternational Journal For Numerical Methods In Biomedical Engineeringen
dc.subjectcoupled electro-mechanical modellingen_IE
dc.subjectdiffuse axonal injuryen_IE
dc.subjectequivalencesen_IE
dc.subjectfinite element modellingen_IE
dc.subjecttraumaen_IE
dc.subjectTRAUMATIC BRAIN-INJURYen_IE
dc.subjectSQUID GIANT-AXONen_IE
dc.subjectSTRETCH-INJURYen_IE
dc.subjectSTRAINen_IE
dc.subjectCOMPRESSIONen_IE
dc.subjectMAGNITUDEen_IE
dc.subjectSYSTEMen_IE
dc.subjectDAMAGEen_IE
dc.titleElectro-mechanical response of a 3D nerve bundle model to mechanical loads leading to axonal injuryen_IE
dc.typeArticleen_IE
dc.date.updated2018-12-11T14:13:36Z
dc.identifier.doi10.1002/cnm.2942
dc.local.publishedsourcehttps://doi.org/10.1002/cnm.2942en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderGalway University Foundationen_IE
dc.contributor.funderCollege of Engineering and Informatics, National University of Ireland, Galwayen_IE
dc.internal.rssid14062840
dc.local.contactMichel Destrade, Room Adb-1002, Áras De Brun, School Of Mathematics, Nui Galway. 2344 Email: michel.destrade@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionSUBMITTED
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