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dc.contributor.authorZhu, Xuming
dc.contributor.authorHuang, Sixia
dc.contributor.authorZhang, Lingling
dc.contributor.authorWu, Yumei
dc.contributor.authorChen, Yingwei
dc.contributor.authorTao, Yixin
dc.contributor.authorWang, Yushu
dc.contributor.authorHe, Shigang
dc.contributor.authorShen, Sanbing
dc.contributor.authorWu, Ji
dc.contributor.authorLi, Baojie
dc.contributor.authorGuo, Xizhi
dc.contributor.authorHe, Lin
dc.contributor.authorMa, Gang
dc.date.accessioned2018-09-20T16:29:06Z
dc.date.available2018-09-20T16:29:06Z
dc.date.issued2014-03-19
dc.identifier.citationZhu, Xuming; Huang, Sixia; Zhang, Lingling; Wu, Yumei; Chen, Yingwei; Tao, Yixin; Wang, Yushu; He, Shigang; Shen, Sanbing; Wu, Ji; Li, Baojie; Guo, Xizhi; He, Lin; Ma, Gang (2014). Constitutive activation of ectodermal β-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure. PLoS ONE 9 (3),
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10379/14537
dc.description.abstractVertebrate limbs originate from the lateral plate mesoderm (LPM) and the overlying ectoderm. While normal limb formation in defined regions has been well studied, the question of whether other positions retain limb-forming potential has not been fully investigated in mice. By ectopically activating beta-catenin in the ectoderm with Msx2-cre, we observed that local tissue outgrowths were induced, which either progressed into limb-like structure within the inter-limb flank or formed extra tissues in other parts of the mouse embryo. In the presumptive abdominal region of severely affected embryos, ectopic limb formation was coupled with impaired abdominal ventral body wall (AVBW) closure, which indicates the existence of a potential counterbalance of limb formation and AVBW closure. At the molecular level, constitutive beta-catenin activation was sufficient to trigger, but insufficient to maintain the ectopic expression of a putative limb-inducing factor, Fgf8, in the ectoderm. These findings provide new insight into the mechanism of limb formation and AVBW closure, and the crosstalk between the Wnt/beta-catenin pathway and Fgf signal.
dc.publisherPublic Library of Science (PLoS)
dc.relation.ispartofPLoS ONE
dc.subjectgenetic interaction
dc.subjectvertebrate limb
dc.subjectmorphogenesis
dc.subjectinitiation
dc.subjectidentity
dc.subjectsignals
dc.subjectridge
dc.subjectfgf10
dc.subjecttbx4
dc.subjectmice
dc.titleConstitutive activation of ectodermal β-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure
dc.typeArticle
dc.identifier.doi10.1371/journal.pone.0092092
dc.local.publishedsourcehttps://doi.org/10.1371/journal.pone.0092092
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