Photoacoustic cardiovascular imaging: a new technique for imaging of atherosclerosis and vulnerable plaque detection
Kolios, Michael C
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Zafar, Haroon; Leahy, Martin; Wijns, William; Kolios, Michael C; Zafar, Junaid; Johnson, Neil; Sharif, Faisal (2018). Photoacoustic cardiovascular imaging: a new technique for imaging of atherosclerosis and vulnerable plaque detection. Biomedical Physics & Engineering Express 4 (3),
The sudden rupture of an atherosclerotic plaque is one of the main causes of stroke and stroke induced death. Plaque composition plays a critical role in plaque rupture. In order to differentiate between different plaque components, an imaging technique suitable for patient follow-up is needed. Photoacoustic (PA) imaging (PAI), a relatively new imaging technique, can also be used for cardiovascular imaging as it resolves optical contrast with ultrasonic resolution, visualizes oxygenated and deoxygenated haemoglobin and a large range of optical agents. PAI can be used to visualize molecular tissue changes, not only stenosis, and relates to the evaluation treatment protocols and/or post-procedural follow-up. In this review, we explain the principles of PAI, describe the recent developments in PAI systems used for non-invasive carotid imaging and intravascular imaging of coronary atherosclerosis and suggest areas of future research that will help bring PAI imaging towards clinical cardiovascular imaging.