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dc.contributor.authorYao, Li
dc.contributor.authorYao, Sheng
dc.contributor.authorDaly, William
dc.contributor.authorHendry, William
dc.contributor.authorWindebank, Anthony
dc.contributor.authorPandit, Abhay
dc.date.accessioned2018-09-20T16:28:49Z
dc.date.available2018-09-20T16:28:49Z
dc.date.issued2012-09-01
dc.identifier.citationYao, Li; Yao, Sheng; Daly, William; Hendry, William; Windebank, Anthony; Pandit, Abhay (2012). Non-viral gene therapy for spinal cord regeneration. Drug Discovery Today 17 (17), 998-1005
dc.identifier.issn1359-6446
dc.identifier.urihttp://hdl.handle.net/10379/14489
dc.description.abstractSpinal cord injury (SCI) normally results in life-long disabilities and a broad range of secondary complications. Advances in therapeutic delivery during the past few decades offer hope for such victims. However, the limited functional improvement shown in in vivo studies hinders effective therapeutic application in clinical practice. Recent studies showed that gene vectors can transfect cells present in the lesion of an injured spinal cord (endogenous cells) and thereby produce therapeutic molecules with long-lasting biological effects that promote neural tissue regeneration. In this article we review recent advances in non-viral gene delivery into neural cells and their use for gene therapy in SCI.
dc.publisherElsevier BV
dc.relation.ispartofDrug Discovery Today
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectmultiple-channel bridges
dc.subjectneural progenitor cells
dc.subjectprimary neurons
dc.subjectplasmid DNA
dc.subjecttransgene expression
dc.subjectin-vitro
dc.subjecttransfection efficiency
dc.subjectinflammatory response
dc.subjectpostmitotic neurons
dc.subjectcorticospinal tract
dc.titleNon-viral gene therapy for spinal cord regeneration
dc.typeArticle
dc.identifier.doi10.1016/j.drudis.2012.05.009
dc.local.publishedsourcehttp://europepmc.org/articles/pmc3586204?pdf=render
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland