Show simple item record

dc.contributor.authorYang, Xiaohong R.
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorGoode, Ellen L.
dc.contributor.authorCouch, Fergus J.
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorMilne, Roger L.
dc.contributor.authorGaudet, Mia
dc.contributor.authorSchmidt, Marjanka K.
dc.contributor.authorBroeks, Annegien
dc.contributor.authorCox, Angela
dc.contributor.authorFasching, Peter A.
dc.contributor.authorHein, Rebecca
dc.contributor.authorSpurdle, Amanda B.
dc.contributor.authorBlows, Fiona
dc.contributor.authorDriver, Kristy
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorHeinz, Judith
dc.contributor.authorSinn, Peter
dc.contributor.authorVrieling, Alina
dc.contributor.authorHeikkinen, Tuomas
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorHeikkilä, Päivi
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorPeplonska, Beata
dc.contributor.authorChanock, Stephen
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorBrinton, Louise
dc.contributor.authorHall, Per
dc.contributor.authorCzene, Kamila
dc.contributor.authorHumphreys, Keith
dc.contributor.authorDarabi, Hatef
dc.contributor.authorLiu, Jianjun
dc.contributor.authorVan ‘t Veer, Laura J.
dc.contributor.authorvan Leeuwen, Flora E.
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorGlendon, Gord
dc.contributor.authorKnight, Julia A.
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorO’Malley, Frances P.
dc.contributor.authorWeerasooriya, Nayana
dc.contributor.authorJohn, Esther M.
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorHartmann, Arndt
dc.contributor.authorWeihbrecht, Sebastian B.
dc.contributor.authorWachter, David L.
dc.contributor.authorJud, Sebastian M.
dc.contributor.authorLoehberg, Christian R.
dc.contributor.authorBaglietto, Laura
dc.contributor.authorEnglish, Dallas R.
dc.contributor.authorGiles, Graham G.
dc.contributor.authorMcLean, Catriona A.
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorLambrechts, Diether
dc.contributor.authorVandorpe, Thijs
dc.contributor.authorWeltens, Caroline
dc.contributor.authorParidaens, Robert
dc.contributor.authorSmeets, Ann
dc.contributor.authorNeven, Patrick
dc.contributor.authorWildiers, Hans
dc.contributor.authorWang, Xianshu
dc.contributor.authorOlson, Janet E.
dc.contributor.authorCafourek, Victoria
dc.contributor.authorFredericksen, Zachary
dc.contributor.authorKosel, Matthew
dc.contributor.authorVachon, Celine
dc.contributor.authorCramp, Helen E.
dc.contributor.authorConnley, Daniel
dc.contributor.authorCross, Simon S.
dc.contributor.authorBalasubramanian, Sabapathy P.
dc.contributor.authorReed, Malcolm W. R.
dc.contributor.authorDörk, Thilo
dc.contributor.authorBremer, Michael
dc.contributor.authorMeyer, Andreas
dc.contributor.authorKarstens, Johann H.
dc.contributor.authorAy, Aysun
dc.contributor.authorPark-Simon, Tjoung-Won
dc.contributor.authorHillemanns, Peter
dc.contributor.authorArias Pérez, Jose Ignacio
dc.contributor.authorRodríguez, Primitiva Menéndez
dc.contributor.authorZamora, Pilar
dc.contributor.authorBenítez, Javier
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorFischer, Hans-Peter
dc.contributor.authorHamann, Ute
dc.contributor.authorPesch, Beate
dc.contributor.authorBrüning, Thomas
dc.contributor.authorJustenhoven, Christina
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorEccles, Diana M.
dc.contributor.authorTapper, William J.
dc.contributor.authorGerty, Sue M.
dc.contributor.authorSawyer, Elinor J.
dc.contributor.authorTomlinson, Ian P.
dc.contributor.authorJones, Angela
dc.contributor.authorKerin, Michael
dc.contributor.authorMiller, Nicola
dc.contributor.authorMcInerney, Niall
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorYang, Show-Lin
dc.contributor.authorYu, Jyh-Cherng
dc.contributor.authorChen, Shou-Tung
dc.contributor.authorHsu, Giu-Cheng
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorKolonel, Laurence N.
dc.contributor.authorLindblom, Annika
dc.contributor.authorMargolin, Sara
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubiński, Jan
dc.contributor.authorHuzarski, Tomasz
dc.contributor.authorByrski, Tomasz
dc.contributor.authorGórski, Bohdan
dc.contributor.authorGronwald, Jacek
dc.contributor.authorHooning, Maartje J.
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorvan den Ouweland, Ans M. W.
dc.contributor.authorJager, Agnes
dc.contributor.authorKriege, Mieke
dc.contributor.authorTilanus-Linthorst, Madeleine M. A.
dc.contributor.authorCollée, Margriet
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorMononen, Kari
dc.contributor.authorGrip, Mervi
dc.contributor.authorHirvikoski, Pasi
dc.contributor.authorWinqvist, Robert
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorKauppinen, Jaana
dc.contributor.authorKataja, Vesa
dc.contributor.authorAuvinen, Päivi
dc.contributor.authorSoini, Ylermi
dc.contributor.authorSironen, Reijo
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorDynnes Ørsted, David
dc.contributor.authorKaur-Knudsen, Diljit
dc.contributor.authorFlyger, Henrik
dc.contributor.authorNordestgaard, Børge G.
dc.contributor.authorHolland, Helene
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorBarile, Monica
dc.contributor.authorRadice, Paolo
dc.contributor.authorHankinson, Susan E.
dc.contributor.authorHunter, David J.
dc.contributor.authorTamimi, Rulla
dc.contributor.authorSangrajrang, Suleeporn
dc.contributor.authorBrennan, Paul
dc.contributor.authorMcKay, James
dc.contributor.authorOdefrey, Fabrice
dc.contributor.authorGaborieau, Valerie
dc.contributor.authorDevilee, Peter
dc.contributor.authorHuijts, P.E.A.
dc.contributor.authorTollenaar, RAEM.
dc.contributor.authorSeynaeve, C.
dc.contributor.authorDite, Gillian S.
dc.contributor.authorApicella, Carmel
dc.contributor.authorHopper, John L.
dc.contributor.authorHammet, Fleur
dc.contributor.authorTsimiklis, Helen
dc.contributor.authorSmith, Letitia D.
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorHumphreys, Manjeet K.
dc.contributor.authorEaston, Douglas
dc.contributor.authorPharoah, Paul
dc.contributor.authorSherman, Mark E.
dc.contributor.authorGarcia-Closas, Montserrat
dc.date.accessioned2018-09-20T16:28:47Z
dc.date.available2018-09-20T16:28:47Z
dc.date.issued2010-12-29
dc.identifier.citationYang, Xiaohong R. Chang-Claude, Jenny; Goode, Ellen L.; Couch, Fergus J.; Nevanlinna, Heli; Milne, Roger L.; Gaudet, Mia; Schmidt, Marjanka K.; Broeks, Annegien; Cox, Angela; Fasching, Peter A.; Hein, Rebecca; Spurdle, Amanda B.; Blows, Fiona; Driver, Kristy; Flesch-Janys, Dieter; Heinz, Judith; Sinn, Peter; Vrieling, Alina; Heikkinen, Tuomas; Aittomäki, Kristiina; Heikkilä, Päivi; Blomqvist, Carl; Lissowska, Jolanta; Peplonska, Beata; Chanock, Stephen; Figueroa, Jonine; Brinton, Louise; Hall, Per; Czene, Kamila; Humphreys, Keith; Darabi, Hatef; Liu, Jianjun; Van ‘t Veer, Laura J.; van Leeuwen, Flora E.; Andrulis, Irene L.; Glendon, Gord; Knight, Julia A.; Mulligan, Anna Marie; O’Malley, Frances P.; Weerasooriya, Nayana; John, Esther M.; Beckmann, Matthias W.; Hartmann, Arndt; Weihbrecht, Sebastian B.; Wachter, David L.; Jud, Sebastian M.; Loehberg, Christian R.; Baglietto, Laura; English, Dallas R.; Giles, Graham G.; McLean, Catriona A.; Severi, Gianluca; Lambrechts, Diether; Vandorpe, Thijs; Weltens, Caroline; Paridaens, Robert; Smeets, Ann; Neven, Patrick; Wildiers, Hans; Wang, Xianshu; Olson, Janet E.; Cafourek, Victoria; Fredericksen, Zachary; Kosel, Matthew; Vachon, Celine; Cramp, Helen E.; Connley, Daniel; Cross, Simon S.; Balasubramanian, Sabapathy P.; Reed, Malcolm W. R.; Dörk, Thilo; Bremer, Michael; Meyer, Andreas; Karstens, Johann H.; Ay, Aysun; Park-Simon, Tjoung-Won; Hillemanns, Peter; Arias Pérez, Jose Ignacio; Rodríguez, Primitiva Menéndez; Zamora, Pilar; Benítez, Javier; Ko, Yon-Dschun; Fischer, Hans-Peter; Hamann, Ute; Pesch, Beate; Brüning, Thomas; Justenhoven, Christina; Brauch, Hiltrud; Eccles, Diana M.; Tapper, William J.; Gerty, Sue M.; Sawyer, Elinor J.; Tomlinson, Ian P.; Jones, Angela; Kerin, Michael; Miller, Nicola; McInerney, Niall; Anton-Culver, Hoda; Ziogas, Argyrios; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Yang, Show-Lin; Yu, Jyh-Cherng; Chen, Shou-Tung; Hsu, Giu-Cheng; Haiman, Christopher A.; Henderson, Brian E.; Le Marchand, Loic; Kolonel, Laurence N.; Lindblom, Annika; Margolin, Sara; Jakubowska, Anna; Lubiński, Jan; Huzarski, Tomasz; Byrski, Tomasz; Górski, Bohdan; Gronwald, Jacek; Hooning, Maartje J.; Hollestelle, Antoinette; van den Ouweland, Ans M. W.; Jager, Agnes; Kriege, Mieke; Tilanus-Linthorst, Madeleine M. A.; Collée, Margriet; Wang-Gohrke, Shan; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Mononen, Kari; Grip, Mervi; Hirvikoski, Pasi; Winqvist, Robert; Mannermaa, Arto; Kosma, Veli-Matti; Kauppinen, Jaana; Kataja, Vesa; Auvinen, Päivi; Soini, Ylermi; Sironen, Reijo; Bojesen, Stig E.; Dynnes Ørsted, David; Kaur-Knudsen, Diljit; Flyger, Henrik; Nordestgaard, Børge G.; Holland, Helene; Chenevix-Trench, Georgia; Manoukian, Siranoush; Barile, Monica; Radice, Paolo; Hankinson, Susan E.; Hunter, David J.; Tamimi, Rulla; Sangrajrang, Suleeporn; Brennan, Paul; McKay, James; Odefrey, Fabrice; Gaborieau, Valerie; Devilee, Peter; Huijts, P.E.A.; Tollenaar, RAEM.; Seynaeve, C.; Dite, Gillian S.; Apicella, Carmel; Hopper, John L.; Hammet, Fleur; Tsimiklis, Helen; Smith, Letitia D.; Southey, Melissa C.; Humphreys, Manjeet K.; Easton, Douglas; Pharoah, Paul; Sherman, Mark E.; Garcia-Closas, Montserrat (2010). Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the breast cancer association consortium studies. JNCI: Journal of the National Cancer Institute 103 (3), 250-263
dc.identifier.issn1460-2105,0027-8874
dc.identifier.urihttp://hdl.handle.net/10379/14483
dc.description.abstractBackground Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. Methods We pooled tumor marker and epidemiological risk factor data from 35 568 invasive breast cancer case patients from 34 studies participating in the Breast Cancer Association Consortium. Logistic regression models were used in case-case analyses to estimate associations between epidemiological risk factors and tumor subtypes, and case-control analyses to estimate associations between epidemiological risk factors and the risk of developing specific tumor subtypes in 12 population-based studies. All statistical tests were two-sided. Results In case-case analyses, of the epidemiological risk factors examined, early age at menarche (<= 12 years) was less frequent in case patients with PR- than PR+ tumors (P = .001). Nulliparity (P = 3 x 10(-6)) and increasing age at first birth (P = 2 x 10(-9)) were less frequent in ER- than in ER+ tumors. Obesity (body mass index [BMI] >= 30 kg/m(2)) in younger women (<= 50 years) was more frequent in ER /PR than in ER+/PR+ tumors (P = 1 x 10(-7)), whereas obesity in older women (>50 years) was less frequent in PR- than in PR+ tumors (P = 6 x 10(-4)). The triple-negative (ER-/PR-/HER2-) or core basal phenotype (CBP; triple-negative and cytokeratins [CK]5/6(+) and/ or epidermal growth factor receptor [EGFR] 1) accounted for much of the heterogeneity in parity-related variables and BMI in younger women. Case-control analyses showed that nulliparity, increasing age at first birth, and obesity in younger women showed the expected associations with the risk of ER+ or PR+ tumors but not triple-negative (nulliparity vs parity, odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.75 to 1.19, P = .61; 5-year increase in age at first full-term birth, OR = 0.95, 95% CI = 0.86 to 1.05, P = .34; obesity in younger women, OR = 1.36, 95% CI = 0.95 to 1.94, P = .09) or CBP tumors. Conclusions This study shows that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofJNCI: Journal of the National Cancer Institute
dc.subjectsingle-nucleotide polymorphisms
dc.subjectdifferent histopathologic types
dc.subjectprogesterone-receptor status
dc.subjectepithelial ovarian-cancer
dc.subjectbasal-like subtype
dc.subjectpostmenopausal women
dc.subjectsusceptibility loci
dc.subjecthormone-receptor
dc.subjectrepair genes
dc.subjectestrogen
dc.titleAssociations of breast cancer risk factors with tumor subtypes: a pooled analysis from the breast cancer association consortium studies
dc.typeArticle
dc.identifier.doi10.1093/jnci/djq526
dc.local.publishedsourcehttps://academic.oup.com/jnci/article-pdf/103/3/250/17311626/djq526.pdf
nui.item.downloads0


Files in this item

This item appears in the following Collection(s)

Show simple item record